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David S. Goldstein, Patricia Sullivan, Courtney Holmes, Gary W. Miller, Yehonatan Sharabi and Irwin J. Kopin A vesicular sequestration to oxidative deamination shift in myocardial sympathetic nerves in Parkinson's disease Journal of Neurochemistry 131

Version of Record online: 13 JUN 2014 | DOI: 10.1111/jnc.12766

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We found that the majority (70%) of Parkinson's disease (PD) patients have profound (98%) myocardial norepinephrine depletion, because of both cardiac sympathetic denervation and a shift from vesicular sequestration to oxidative deamination of cytoplasmic catecholamines in the residual nerves. This shift may be part of a final common pathogenetic pathway in the loss of catecholaminergic neurons that characterizes PD.

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