Mrudang Shah, Subramanian Rajagopalan, Liping Xu, Chandrashekhar Voshavar, Yevgeniya Shurubor, Flint Beal, Julie K. Andersen and Aloke K. Dutta The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease Journal of Neurochemistry 131
Neuroprotective properties of dopamine D2/D3 agonist D-512 was evaluated both in vitro and in vivo models of Parkinson's disease (PD). D-512 rescued PC12 cells from toxicity induced by 6-hydroxydopamine (6-OHDA). D-512 reduced intracellular reactive oxygen species and lipid peroxidation as well as protection of DNA damage from toxicity of 6-OHDA. D-512 was protective against neurodegenerative phenotypes induced by MPTP in mouse. Our studies strongly suggest that D-512 with its multifunctional property may constitute a novel viable therapy for Parkinson's disease.
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