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Junhui Wang, Jinping Qiao, Yanbo Zhang, Hongxing Wang, Shenghua Zhu, Handi Zhang, Kelly Hartle, Huining Guo, Wei Guo, Jue He, Jiming Kong, Qingjun Huang and Xin-Min Li Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate-limiting enzyme of cholesterol synthesis in a chronic mouse model of depression Journal of Neurochemistry 131

Version of Record online: 8 JUL 2014 | DOI: 10.1111/jnc.12792

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We examined the possible role of oligodendrocyte and myelin in the pathological changes of depression with an unpredictable chronic mild stress (UCMS) mouse model. Oligodendrocyte-related proteins in the mouse brain were specifically changed during the stress period. The depressive-like behaviors and oligodendrocyte deficits could be prevented by the administration of desvenlafaxine. Oligodendrocyte and myelin may be an essential target of desvenlafaxine for the treatment of depression.

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