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Cécile Batandier, Laurent Poulet, Isabelle Hininger, Karine Couturier, Eric Fontaine, Anne-Marie Roussel and Frédéric Canini Acute stress delays brain mitochondrial permeability transition pore opening Journal of Neurochemistry 131

Version of Record online: 31 JUL 2014 | DOI: 10.1111/jnc.12811

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In a rat model of acute restraint stress, we observed substantial changes in brain mitochondria functioning. Stress significantly (i) delays (43%) the opening of permeability transition pore (PTP) by the calcium (Ca2+), its main inductor and (ii) results in an inhibition of complex I in electron transport chain associated with change in AMPK signaling pathway. These data suggest an adaptive mechanism of brain mitochondria in stressed condition, with a special focus on PTP regulation.

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