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Tarcyane Barata Garcia, Thomas Pannicke, Stefanie Vogler, Benjamin-Andreas Berk, Antje Grosche, Peter Wiedemann, Johannes Seeger, Andreas Reichenbach, Anderson Manoel Herculano and Andreas Bringmann Nerve growth factor inhibits osmotic swelling of rat retinal glial (Müller) and bipolar cells by inducing glial cytokine release Journal of Neurochemistry 131

Version of Record online: 8 AUG 2014 | DOI: 10.1111/jnc.12822

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Cytotoxic cell swelling contributes to retinal neurodegeneration. Nerve growth factor (NGF) inhibits the osmotic swelling of glial cells by acting at TrkA, release of bFGF, and opening of K+ and Cl channels. The NGF-induced glial release of cytokines like bFGF inhibits the osmotic swelling of bipolar cells, suggesting that the neuroprotective effect of NGF is in part mediated by prevention of cytotoxic cell swelling.

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