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Anantha Vijay R. Santhanam, Livius V. d'Uscio and Zvonimir S. Katusic Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling Journal of Neurochemistry 131

Version of Record online: 6 AUG 2014 | DOI: 10.1111/jnc.12824

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We demonstrate that treatment with erythropoietin (EPO) could protect cerebral microvasculature against the pathological consequences of endothelial nitric oxide (NO) synthase uncoupling. Our results suggest that EPO might protect the neurovascular unit against oxidative stress by restoring bioavailability of tetrahydrobiopterin (BH4) and endothelial nitric oxide.

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