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Feng Gu, Li Wang, Jia He, Xiaoli Liu, Huikun Zhang, Wenliang Li, Li Fu and Yongjie Ma Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells Journal of Neurochemistry 131

Article first published online: 12 AUG 2014 | DOI: 10.1111/jnc.12831

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We show that reduction of Girdin, an actin-binding protein, leads to impaired F-actin polymerization and down-regulated expression of matrix metallopeptidase protein 2 (MMP-2), phosphorylated integrin β1, and phosphorylated focal adhesion kinase (FAK), which resulted in decreased migration, adhesion, and invasion of glioblastoma cells. Girdin was positively correlated with glioma malignancy and negatively associated with clinical prognosis, suggesting Girdin as a critical regulator in glioma infiltration.

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