Stefania Averaimo, Marta Gritti, Erica Barini, Laura Gasparini and Michele Mazzanti CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells Journal of Neurochemistry 131
Using a combination of electrophysiology and immunohistochemistry, we found that the chloride intracellular channel 1 (CLIC1) protein modulates the speed of neurite growth. The chloride current mediated by CLIC1 is essential for maintaining growth cone morphology and is required for sustaining cAMP-stimulated neurite elongation in dissociated immunopurified neurons. The presence of either the CLIC1 current blocker IAA94 or the anti-CLIC1 antibody inhibits neurite growth of Retina Ganglion Cells cultured in the presence of 10 micromolar forskolin for 24 h.
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