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D.H. Zhao, Y. Yu, Y.F. Zhou, W. Shi, H. Deng and Y.H. Liu Postantibiotic effect and postantibiotic sub-minimum inhibitory concentration effect of valnemulin against Staphylococcus aureus isolates from swine and chickens Letters in Applied Microbiology 58

Version of Record online: 23 OCT 2013 | DOI: 10.1111/lam.12168

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Significance and Impact of the Study: In this study, valnemulin demonstrated prolonged postantibiotic effects and postantibiotic sub-MIC effects on strains of Staphylococcus aureus. The strains with identical MICs of valnemulin exhibited different PAEs and PA-SMEs. Staphylococcus aureus isolated from different species has little impact on the postantibiotic effect of valnemulin. The result suggests a longer dosing interval while formulating a daily administration dosage, and it may play a valuable role of valnemulin in treating Staph. aureus infections in animals.

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