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G. Di Nardo, G. Barbara, S. Cucchiara, C. Cremon, R. J. Shulman, S. Isoldi, L. Zecchi, L. Drago, S. Oliva, R. Saulle, M. R. Barbaro and L. Stronati Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS Neurogastroenterology & Motility 26

Version of Record online: 7 NOV 2013 | DOI: 10.1111/nmo.12250

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The relevance of mast cells and neuroimmune interaction in children with IBS is still unknown. We assessed in the ileal and colonic mucosa of children with IBS mast cell infiltration, mast cell-nerve interactions, and their correlations with symptoms. The number of mast cells in close proximity to nerves both in the ileal and colonic mucosa was increased and related to the intensity and frequency of abdominal pain.

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