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Toru Kubota, Tatsushi Toyooka and Yuko Ibuki Nonylphenol Polyethoxylates Degraded by Three Different Wavelengths of UV and Their Genotoxic Change—Detected by Generation of γ-H2AX Photochemistry and Photobiology 89

Version of Record online: 30 OCT 2012 | DOI: 10.1111/php.12002

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The long ethylene oxide (EO) chain of a nonylphenolpolyethoxylate(NPEO[70]) was broken near the benzene ring by UV, producing NPEOs with a short EO chain (around 10 units). NPEO(10) was further degraded and disappeared. The effect was dependent on the energy of UV. A genotoxic marker, phosphorylation of histone H2AX (γ-H2AX), was generated according to the degradation patterns; shortening of the EO chain changed NPEO(70) into an inducer for γ-H2AX, and degradation of NPEO(10) attenuated the genotoxicity. UV rays can make NPEOs harmless orgenotoxic according to the degradation of EO side-chains.

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