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Ozden Tacal, Bin Li, Oksana Lockridge and Lawrence M. Schopfer Resistance of Human Butyrylcholinesterase to Methylene Blue-Catalyzed Photoinactivation; Mass Spectrometry Analysis of Oxidation Products Photochemistry and Photobiology 89

Article first published online: 17 DEC 2012 | DOI: 10.1111/php.12016

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Irradiation of butyrylcholinesterase (BChE) in the presence of methylene blue results in a variety of oxidations typical of phenothiazine photochemistry of proteins (hydroxylated methionine, hydroxylated tryptophan, kynurenine, N-formyl-kynurenine, hydroxylated and peroxidized-cysteine), but in addition there are novel oxidations (oxidation of serine, oxidation of histidine, 3-OH-kynurenine) and there is extensive protein degradation such that when the enzymatic activity is finally eliminated there is little to no intact protein remaining.

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