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Mark D. Savellano, Nicci Owusu-Brackett, Ji Son, Tanay Ganga, Nadia L. Leung and Dagmar H. Savellano Photodynamic Tumor Eradication With a Novel Targetable Photosensitizer: Strong Vascular Effects and Dependence on Treatment Repetition Versus Potentiation Photochemistry and Photobiology 89

Version of Record online: 27 DEC 2012 | DOI: 10.1111/php.12018

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To potentiate and improve the targeting of photodynamic therapy (PDT), an amphiphilic polyethylene glycolated pyropheophorbide-a (PPa) derivative, Ac-sPPp, was investigated as a novel water-soluble photosensitizer that could be easily coupled to cancer-targeting molecules or combined with other therapeutics. In a recurrent A-431 tumor xenograft model, passively and actively targeted Ac-sPPp formulations exerted strong vascular effects and provided superior fluorescence contrast and tumor control compared to PPa, but efforts to improve targeting and potency by formulating Ac-sPPp as an anti-erbB immunoconjugate or combining it with Doxil chemotherapy were less important to achieving tumor cures than simply repeating PDT.

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