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Maria Zaidi, John G. Krolikowki, Deron W. Jones, Kirkwood A. Pritchard Jr, Janine Struve, Sandhya D. Nandedkar, Nicole L. Lohr, Paul S. Pagel and Dorothée Weihrauch Transient Repetitive Exposure to Low Level Light Therapy Enhances Collateral Blood Vessel Growth in The Ischemic Hindlimb of The Tight Skin Mouse Photochemistry and Photobiology 89

Article first published online: 7 JAN 2013 | DOI: 10.1111/php.12024

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Collateral growth is impaired in the ischemic hindlimb in a murine model of scleroderma. Impaired collateral growth is characterized by increased levels of the angiogenesis inhibitor angiostatin and decreased levels of the pro-angiogenic protein angiomotin. Low-level light therapy (LLLT) induced topical nitric oxide release which restored collateral growth by reducing the expression levels of the angiostatin by increasing topical nitric oxide levels and the expression of angiomotin. Low-level light therapy stimulates angiogenesis by increasing angiomotin and decreasing angiostatin expression in the ischemic hindlimb in the murine scleroderma.

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