Shany Ytzhak, Hana Weitman and Benjamin Ehrenberg The Effect of Lipid Composition on the Permeability of Fluorescent Markers from Photosensitized Membranes Photochemistry and Photobiology 89
We examined the permeation of large fluorescent molecules through the liposomal membrane as a result of photodynamic damage. Liposomes containing high concentration of self-quenched dye have almost no fluorescence. When the lipid bilayer is damaged, the dye is released to the outer phase, it is diluted and it becomes highly fluorescent. We found that as the degree of fatty acid unsaturation increased the photosensitized passage of these molecules through the bilayer increased.
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