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Stuart Ibsen, Eran Zahavy, Wolf Wrasidlo, Tomoko Hayashi, John Norton, Yongxuan Su, Stephen Adams and Sadik Esener Localized In Vivo Activation of a Photoactivatable Doxorubicin Prodrug in Deep Tumor Tissue Photochemistry and Photobiology 89

Version of Record online: 6 MAR 2013 | DOI: 10.1111/php.12045

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Reducing the side effects of chemotherapy treatment involves reducing the amount of active agent that reaches the healthy tissue while simultaneously increasing the amount within the tumor. This study looks to achieve these goals by using a systemically distributed photocleavable prodrug of doxorubicin and activating it specifically in tumor tissue with the use of a fiber-optic/LED system that delivers the activating wavelength of light to the center of the tumor. The doxorubicin prodrug was 200 times less toxic than the pure doxorubicin that was released from it. Here, we show that a six-fold increase in pure doxorubicin was found in the light-exposed tumor versus the neighboring unexposed control tumor.

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