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Makoto Kunisada, Taro Masaki, Ryusuke Ono, Hironobu Morinaga, Eiji Nakano, Flandiana Yogianti, Kunihiro Okunishi, Hiroshi Sugiyama and Chikako Nishigori Hydrochlorothiazide Enhances UVA-Induced DNA Damage Photochemistry and Photobiology 89

Article first published online: 25 FEB 2013 | DOI: 10.1111/php.12048

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Various drugs have been reported to cause photosensitive drug eruptions as an adverse effect. We tested whether photosensitive drugs could enhance CPD formation after UVA exposure by using isolated DNA in the presence of several photosensitive drugs using high-performance liquid chromatography. The diuretic agent hydrochlorothiazide (HCT) significantly enhanced the production of thymine dimers over a wide range of UVA. We also investigated whether UVA plus HCT could enhance CPD production in mice skin. Immunofluorescence studies showed that CPD formation in the dermal skin significantly increased after 365 nm narrow-band UVA irradiation in the presence of HCT.

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