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Viktor Pajer, Ákos Tiboldi, Narkhyun Bae, Kongzhao Li, Sung Ung Kang, Béla Hopp, Lajos Kolozsvári, Gert Lubec and Antal Nógrádi The Molecular Background of the Differential UV Absorbance of the Human Lens in the 240–400 nm Range Photochemistry and Photobiology 89

Article first published online: 18 MAR 2013 | DOI: 10.1111/php.12063

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Although the cornea absorbs most of the ultraviolet (UV) radiation, still considerable radiation may reach the lens. By measuring the UV absorption of human lens sections we found that the UV-C and UV-B absorption of the human lens increased toward the posterior parts of the lens. Two-dimensional gel electrophoresis and mass spectroscopy analysis identified significantly different protein spots in the anterior and posterior section pools. Beta-crystallin B2 and A3 along with glyceraldehyde 3-phosphate dehydrogenase were enriched in the anterior part of the lens while elevated levels of Alpha-crystallin A chain and Beta-crystallin B1 proteins were found in the posterior portion.

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