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Sreevidya Santha and Chandradhar Dwivedi α-Santalol, A Skin Cancer Chemopreventive Agent with Potential to Target Various Pathways Involved in Photocarcinogenesis Photochemistry and Photobiology 89

Version of Record online: 1 APR 2013 | DOI: 10.1111/php.12070

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Topical treatment of SKH-1 hairless mice with α-santalol, a terpenoid isolated from santalum tree, caused reduction in tumor incidence, multiplicity and volume in UVB-induced skin carcinogenesis. In this study, the anticarcinogenic action of α-santalol against UVB-induced photocarcinogenesis was found to be associated with inhibition of inflammation and epidermal hyperplasia, cell cycle arrest and induction of apoptosis. Our results suggest that α-santalol is a safer and promising skin cancer chemopreventive agent with potential to target various pathways involved in photocarcinogenesis.

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