Ethel J. Ngen, Lixin Xiao, Pallavi Rajaputra, Xingzhong Yan and Youngjae You Enhanced Singlet Oxygen Generation from a Porphyrin–Rhodamine B Dyad by Two-Photon Excitation through Resonance Energy Transfer Photochemistry and Photobiology 89
The two-photon photophysical properties of a porphyrin–rhodamine B conjugate (TPP-Rh), previously demonstrated to target the mitochondria, were evaluated such as TPA cross sections (σ2), RET kinetics, dynamics and singlet oxygen generation. Approximately doubled σ2 of TPP-Rh (40 ± 4 GM) compared with its parent porphyrin (16 ± 4 GM) was measured. Furthermore, TPP-Rh produced singlet oxygen at a significantly faster rate than its parent porphyrin. This study indicates that conjugating photosensitizers to Rh B could provide greater TPA at near-infrared range.
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