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Kim Burnham, Kurt Schuster, Aurora Shingledecker, Robert Kornegay and Jeffrey Oliver Effect of Laser Thermal Injury on Langerhans Cells in Mouse and Hairless Guinea Pig Epidermis Photochemistry and Photobiology 89

Version of Record online: 5 JUN 2013 | DOI: 10.1111/php.12092

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Mice and hairless guinea pigs were exposed to a thulium laser at a wavelength of 2.0 μm. Mouse skin exhibited histological evidence of thermal damage and decreases in epidermal Langerhans cells at 24 and 48 h following doses from 0.14 to 0.56 W. In contrast, hairless guinea pig skin only showed consistent histological evidence of thermal damage and the disappearance of Langerhans cells following the highest dose administered (0.70 W). These results suggest a correlation between thermal damage and Langerhans cell disappearance for both mice and hairless guinea pigs.

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