Marie Vikdal, Anette Weyergang, Pål Kristian Selbo and Kristian Berg Vascular endothelial cells as targets for photochemical internalization (PCI) Photochemistry and Photobiology 89
Photochemical internalization (PCI) utilizes photosensitizers localizing to endo-lysosomes in order to release drugs taken up by endocytosis. In order to study sensitivity of PCI in vasculature, this study compares uptake and localization of two of these photosensitizers, AlPcS2a and TPPS2a, in vascular endothelial cells (HUVECs) and fibrosarcoma cells (HT1080). Photosensitizer uptake was found to be much higher in HUVECs compared to in HT1080 cells, while intracellular localization was similar. Efficacy of PCI are estimated and discussed in the study.
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