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Chrysie Aggelidou, Theodossis A. Theodossiou and Konstantina Yannakopoulou Protoporphyrin IX–β-Cyclodextrin Bimodal Conjugate: Nanosized Drug Transporter and Potent Phototoxin Photochemistry and Photobiology 89

Article first published online: 29 JUL 2013 | DOI: 10.1111/php.12127

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The new, water soluble, covalent conjugate of protoporphyrin IX (PpIX) with β-cyclodextrin (PpIX + βCD) was specifically prepared for multimodal application: PpIX + βCD displays phototoxiciy comparable to that of PpIX, preferentially localizes in mitochondria in MCF7 and DU145 cell lines, effectively solubilizes the breast cancer drug tamoxifen metabolite N-desmethyltamoxifen in water and transports it into cells, where it confers cell death through a synergy of photo- and chemo- toxicity while simultaneously its fluorescence serves for imaging purposes.

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