Kun Li, Mei Wang, Ting Wang, Dongmei Sun, Rongrong Zhu, Xiaoyu Sun, Xianzheng Wu and Shi-Long Wang Interaction of Retinoic Acid Radical Cation with Lysozyme and Antioxidants: Laser Flash Photolysis Study in Microemulsion Photochemistry and Photobiology 89
355 nm laser flash photolysis of all-trans retinoic acid (ATRA) in microemulsion leads to the formation of retinoic acid cation radicals (ATRA•+) via biphotonic processes. Deprotonated form of ATRA is more favorable for the formation of ATRA•+. ATRA•+ is proved to be reactive to lysozyme, tyrosine and tryptophan which is suggestive of its destructive effect on proteins. Meanwhile, some antioxidants, such as curcumin, gallic acid and vitamin C, can efficiently interact with ATRA•+, which indicates that it may competitively protect proteins from the attack of ATRA•+ by inactivating free radical.
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