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Fouzi El Magraoui, Rebecca Brinkmeier, Andreas Schrötter, Wolfgang Girzalsky, Thorsten Müller, Katrin Marcus, Helmut E. Meyer, Ralf Erdmann and Harald W. Platta Distinct Ubiquitination Cascades Act on the Peroxisomal Targeting Signal Type 2 Co-receptor Pex18p Traffic 14

Version of Record online: 7 OCT 2013 | DOI: 10.1111/tra.12120

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The peroxisomal targeting signal type 2 co-receptor Pex18p is polyubiquitinated on lysine residues and monoubiquitinated on a conserved cysteine. In this study, we have identified the two corresponding ubiquitination cascades that catalyze these modifications. We demonstrate that polyubiquitination of Pex18p requires the ubiquitin-conjugating enzyme (E2) Ubc4p, which cooperates with the RING (really interesting new gene)-type ubiquitin-protein ligases (E3) Pex2p as well as Pex10p. Monoubiquitination of Pex18p is catalyzed by the E2 enzyme Pex4p which acts in concert with the E3 enzymes Pex12p and Pex10p.

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