Helen L. Johns, Claudia Gonzalez-Lopez, Charlotte L. Sayers, Michael Hollinshead and Gillian Elliott Rab6 Dependent Post-Golgi Trafficking of HSV1 Envelope Proteins to Sites of Virus Envelopment Traffic 15
As regulators of vesicular transport, Rab GTPases are prime candidates to function in the trafficking of virus glycoproteins. We have found that Golgi-associated Rab6 is crucial for herpes simplex virus 1 glycoprotein transport from the Golgi to the plasma membrane, a process that involves the Rab6 effector ERC1, and the redistribution of Rab6 positive vesicles to the cell periphery. This Rab6-specific step is essential for virus production, indicating glycoprotein transport to the plasma membrane is a prerequisite for envelopment.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf