Jordan Wesolowski and Fabienne Paumet Escherichia coli Exposure Inhibits Exocytic SNARE-Mediated Membrane Fusion in Mast Cells Traffic 15
Mast cell degranulation plays a major role in allergic diseases. Here, we report that co-culturing mast cells with E. coli inhibits FcεRI-mediated degranulation by impacting the function of the exocytic SNARE fusion machinery. In particular, E. coli co-culture reduces the IKKβ-dependent phosphorylation of the t-SNARE SNAP23, thus impairing the formation of ternary exocytic SNARE complexes and ultimately mediator release.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf