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Jordan Wesolowski and Fabienne Paumet Escherichia coli Exposure Inhibits Exocytic SNARE-Mediated Membrane Fusion in Mast Cells Traffic 15

Version of Record online: 7 MAR 2014 | DOI: 10.1111/tra.12159

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Mast cell degranulation plays a major role in allergic diseases. Here, we report that co-culturing mast cells with E. coli inhibits FcεRI-mediated degranulation by impacting the function of the exocytic SNARE fusion machinery. In particular, E. coli co-culture reduces the IKKβ-dependent phosphorylation of the t-SNARE SNAP23, thus impairing the formation of ternary exocytic SNARE complexes and ultimately mediator release.

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