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Katrine L. Voie, Benjamin E. Lucas, David Schaeffer, Dewey Kim, Karen L. Campbell and Sidonie N. Lavergne The effect of ‘allergenic’ and ‘nonallergenic’ antibiotics on dog keratinocyte viability in vitro Veterinary Dermatology 24

Version of Record online: 11 SEP 2013 | DOI: 10.1111/vde.12060

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Background – Immune-mediated adverse drug reactions (drug hypersensitivity) are relatively common in veterinary medicine, but their pathogenesis is not well understood. For an unknown reason, delayed drug hypersensitivity often targets the skin. Antibiotics, especially β-lactams and sulfonamides, are commonly associated with these adverse events. The ‘danger theory’ hypothesizes that ‘danger’ signals, such as drug-induced cell death, might be part of the pathogenesis of drug hypersensitivity reactions. Hypothesis/Objectives – The goal of this study was to determine whether antibiotics that are commonly associated with cutaneous drug hypersensitivity (allergenic) decrease canine keratinocyte viability in vitro more than antibiotics that rarely cause such reactions (nonallergenic). Conclusion – It appears that the effect of drugs on the in vitro viability of dog keratinocytes is not a good predictor of the ‘allergenic’ potential of an antibiotic. Further work is required to investigate other drug-induced ‘danger’ signals in dog keratinocytes exposed to ‘allergenic’ antibiotics in vitro.

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