Heather D. Akridge, Shelley C. Rankin, Gregory C. Griffeth, Raymond C. Boston, Nancy E. Callori and Daniel O. Morris Evaluation of the affinity of various species and strains of Staphylococcus to adhere to equine corneocytes Veterinary Dermatology 24
Background – Meticillin-resistant Staphylococcus aureus (MRSA) strain USA 500 predominately colonizes horses and people working with them. Previous studies demonstrate that some Staphylococcus species exhibit higher affinity for corneocytes of specific mammalian species. Hypothesis/Objectives – The objective was to determine the relative affinities of various MRSA strains, meticillin-susceptible S. aureus (MSSA) strains and a meticillin-susceptible Staphylococcus pseudintermedius (MSSP) for equine corneocytes. We hypothesized that MRSA strain USA 500 would exhibit greater adhesion than other staphylococcal strains tested. Conclusions and clinical importance – Meticillin-resistant S. aureus strain USA 500 did not adhere more robustly than other strains of Staphylococcus; therefore, its affinity to colonize horses may not be solely attributed to corneocyte adhesion. Additional studies are required to explain the epidemiological role of this strain as the predominant cause of colonization and infections of horses in North America.
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