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Linda A. Frank and Jacqueline B. Watson Treatment of alopecia X with medroxyprogesterone acetate Veterinary Dermatology 24

Article first published online: 2 SEP 2013 | DOI: 10.1111/vde.12073

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Background – Alopecia X is a common cause of noninflammatory alopecia in Pomeranian dogs. In the past, treatment with growth hormone injections resulted in hair regrowth in many individuals. Progesterone can induce mammary-derived growth hormone and is used to treat dogs with congenital growth hormone deficiency. Hypothesis/Objectives – To determine whether progesterone induces endogenous insulin-like growth factor-1 (IGF-1) and causes hair regrowth in dogs with alopecia X. Conclusions and clinical importance – Results of this study showed that medroxyprogesterone injections resulted in partial hair regrowth in three and complete hair regrowth in one of eight Pomeranian dogs with alopecia X.

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