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Huai-Xing Wang and Wen-Jun Gao Development of calcium-permeable AMPA receptors and their correlation with NMDA receptors in fast-spiking interneurons of rat prefrontal cortex The Journal of Physiology 588

Article first published online: 3 AUG 2010 | DOI: 10.1113/jphysiol.2010.187591

Abnormal influx of calcium contributes to the neuronal injury in a number of brain disorders. Calcium-permeable AMPA receptors (CP-AMPARs) play a critical role in the pathological process. We found that most of the inhibitory fast-spiking (FS) interneurons in the prefrontal cortex exhibit CP-AMPARs. These cells demonstrate many distinct physiological properties, including few or no NMDA receptors and prominent frequency-dependent short-term facilitation. The CP-AMPA receptors also exhibit dramatic changes during cortical development with a significant decrease in rectification index and an increase in paired-pulse facilitation during adolescence. These data suggest that CP-AMPARs may make FS interneurons particularly vulnerable to disruptive influences in the prefrontal cortex, thus contributing to the onset of many psychiatric disorders.

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