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Ken Kobayashi, Hideki Miwa and Masato Yasui Inflammatory mediators weaken the amniotic membrane barrier through disruption of tight junctions The Journal of Physiology 588

Version of Record online: 15 DEC 2010 | DOI: 10.1113/jphysiol.2010.197764

Chorioamnionitis increases the risk of mortality and morbidity in newborn infants because of amniotic fluid infection. However, the mechanism by which this infection crosses the amniotic barrier and spreads into the amniotic fluid remains unclear. In this study, we have shown that inflammation weakens the amniotic barrier and that this effect is induced by inflammatory mediators, such as interleukin-1β, interleukin-6, tumour necrosis factor-α, and prostaglandin E2, in distinctly different ways. Knowledge of the mechanism underlying the weakening of the amniotic barrier aids in increasing our understanding of the mechanism underlying antenatal infection.

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