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Brett S. Kirby, Anne R. Crecelius, Wyatt F. Voyles and Frank A. Dinenno Vasodilatory responsiveness to adenosine triphosphate in ageing humans The Journal of Physiology 588

Version of Record online: 14 OCT 2010 | DOI: 10.1113/jphysiol.2010.197814

The innermost lining of a blood vessel (endothelium) is important for increasing vessel diameter and facilitating increases in blood flow and oxygen delivery to muscle. This process is typically impaired in older adults. We demonstrate that increases in blood flow to the naturally circulating vessel relaxant, ATP, are intact in older adults who have an impaired innermost lining of muscle blood vessels. Our results show that an unhealthy endothelium does not always translate to an inability to relax blood vessels and aids in the overall understanding of how blood vessels control oxygen delivery to muscle as humans get older.

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