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Francesco Agostini, Luciano Dalla Libera, Jörn Rittweger, Sara Mazzucco, Mihaela Jurdana, Igor B. Mekjavic, Rado Pišot, Luisa Gorza, Marco Narici and Gianni Biolo Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach The Journal of Physiology 588

Version of Record online: 15 DEC 2010 | DOI: 10.1113/jphysiol.2010.198283

Evidence in animals suggests that during inactivity oxidative stress could induce muscle atrophy through enhancement of reactive oxygen species and deregulation of antioxidant systems. We showed that glutathione availability and protein oxidative stress markers were enhanced in atrophying muscles. Increases of protein oxidation were directly related to increases of muscle atrophy induced by inactivity. Thus, in the present work we show that muscle oxidative stress is associated to wasting processes after a long term period of inactivity. Glutathione kinetic upregulation, assessed by a newly validated method, was considered as a response to an increase in oxidative stress. This suggests that glutathione can potentially counteract inactivity mediated muscle atrophy.

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