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Koichi R Katsumura, Chenxi Yang, Meghan E Boyer, Lingjun Li and Emery H Bresnick Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2 EMBO reports 15

Version of Record online: 23 JUL 2014 | DOI: 10.15252/embr.201438808

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This study shows that p38α increases GATA-2 activity at endogenous target genes by inducing GATA-2 multi-site phosphorylation. Oncogenic Ras is found to amplify this mechanism, which provides a potential molecular explanation for the cooperative promotion of cancer development by Ras and GATA-2.

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