Leigh Goedeke, Alessandro Salerno, Cristina M Ramírez, Liang Guo, Ryan M Allen, Xiaoke Yin, Sarah R Langley, Christine Esau, Amarylis Wanschel, Edward A Fisher, Yajaira Suárez, Angel Baldán, Manuel Mayr and Carlos Fernández-Hernando Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice EMBO Molecular Medicine 6
Article first published online: 18 JUL 2014 | DOI: 10.15252/emmm.201404046
Although short-term anti-miR-33 therapy was reported to increase circulating HDL-cholesterol and reduce atherosclerosis, long-term adverse effects are here shown for the 1st time in mice fed a high-fat-diet to result in hypertriglyerimedia and moderate hepatic steatosis.
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