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Julien Diana and Agnès Lehuen Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes EMBO Molecular Medicine 6

Version of Record online: 26 JUN 2014 | DOI: 10.15252/emmm.201404144

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This study reveals the interaction between inflammatory macrophages and β-cells leading to the recruitment of diabetogenic neutrophils in the pancreas of neonatal mice via CXCR2/CXCR2 ligands. Inhibition of CXCR2 reduces the diabetogenic T-cell response, insulitis, and incidence of diabetes.

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