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International Journal of Eating Disorders

Weight-for-length trajectories in the first year of life in children of mothers with eating disorders in a large norwegian cohort

Authors

  • Eliana M. Perrin MD, MPH,

    Corresponding author
    1. Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina
    • Correspondence to: Cynthia Bulik, PhD; CB #7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. E-mail: cbulik@med.unc.edu

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  • Ann Von Holle MS,

    1. Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina
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  • Stephanie Zerwas PhD,

    1. Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina
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  • Asheley Cockrell Skinner PhD,

    1. Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina
    2. Department of Health Policy and Management, University of North Carolina, Chapel Hill, North Carolina
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  • Lauren Reba-Harrelson PhD,

    1. Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina
    2. Department of Psychology, University of North Carolina, Chapel Hill, North Carolina
    3. Harrelson Forensics, Atlanta, GA
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  • Robert M. Hamer PhD,

    1. Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina
    2. Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina
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  • Camilla Stoltenberg MD, dr Med,

    1. Department of Psychiatry, University of Oslo, Norway
    2. Division of Mental Health, Norwegian Institute of Public Health, Norway
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  • Leila Torgersen PhD,

    1. Division of Mental Health, Norwegian Institute of Public Health, Norway
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  • Ted Reichborn-Kjennerud MD, dr Med,

    1. Division of Epidemiology, Norwegian Institute of Public Health, Norway
    2. Institute of Psychiatry, University of Oslo, Oslo, Norway
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  • Cynthia M. Bulik PhD

    1. Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina
    2. Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina
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  • Dr. Bulik is a consultant for Shire Pharmaceuticals.

  • This study was supported by “http://projectreporter.nih.gov/project_info_details.cfm?aid=7152509&icde=7012324”&&R01HD047186 (Bulik: PI). The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (grant no N01-ES-85433), NIH/NINDS (grant no.1 UO1 NS 047537-01), and the Norwegian Research Council/FUGE (grant no. 151918/S10). Drs. Skinner and Zerwas were supported by an NIH Building Interdisciplinary Careers in Women's Health award (K12-HD01441). Dr. Zerwas is supported by a NIMH training grant (K01MH100435). Dr. Reba-Harrelson was supported by the Ruth L. Kirschstein National Research Service Award. The authors report no conflicts of interest relevant to the content of this article.

ABSTRACT

Objective

To describe weight-for-length (WFL) trajectories in the children (birth-12 months) of mothers with and without eating disorders.

Method

This study is based on the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. We categorized women (N = 57,185) based on diagnosis prior to and during pregnancy: anorexia nervosa, bulimia nervosa, eating disorder not otherwise specified-purging subtype, binge eating disorder, or no eating disorder. The primary analysis included a shape invariant model fitted with nonlinear mixed effects to compare growth rates across eating disorder subtypes.

Results

The children of mothers reporting any eating disorder had a lower WFL growth rate from birth to 12 months than the children of mothers without eating disorders, even after adjusting for relative birth weight and some confounders known to affect growth.

Discussion

In this cohort, child WFL was related to maternal eating disorder status before and/or during pregnancy. These differences in growth trajectories warrant further study of long-term health outcomes and, if replicated, tailoring counseling to mothers with eating disorders during pregnancy. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014)

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