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Pediatric Transplantation

Recurrence of granulomatous interstitial nephritis in transplanted kidney


V. Matti Vehaskari, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
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Vargas F, Gedalia A, Craver RD, Vehaskari VM. Recurrence of granulomatous interstitial nephritis in transplanted kidney.
Pediatr Transplantation 2010: 14:e54–e57. © 2009 John Wiley & Sons A/S.

Abstract:  Sarcoidosis is a multisystemic disease of unknown etiology. Minor renal involvement is not rare but kidney failure is uncommon and only rare cases of recurrent disease in a kidney transplant have been published. We report a patient who at age 10 yr developed ESRD secondary to renal sarcoidosis with GIN. Her disease subsequently recurred in the transplanted kidney despite standard immunosuppression with prednisone, tacrolimus, and mycophenolate mofetil. The recurrent disease appeared to respond to increased immunosuppression, which included infliximab. However, the patient died of disseminated histoplasmosis three yr post-transplant.

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