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European Journal of Neuroscience

Epigenetic regulation of neurogenesis in the adult mammalian brain

Authors

  • Jiaqi Sun,

    1. School of Life Sciences, Tsinghua University, Beijing, China
    2. Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB 759, Baltimore, MD 21205, USA
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  • Jiawei Sun,

    1. School of Life Sciences, Tsinghua University, Beijing, China
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  • Guo-li Ming,

    1. Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB 759, Baltimore, MD 21205, USA
    2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    3. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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  • Hongjun Song

    1. Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB 759, Baltimore, MD 21205, USA
    2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    3. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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Dr H. Song,2 Institute for Cell Engineering, as above.
E-mail: shongju1@jhmi.edu

Abstract

Epigenetic regulation represents a fundamental mechanism to maintain cell-type-specific gene expression during development and serves as an essential mediator to interface the extrinsic environment and the intrinsic genetic programme. Adult neurogenesis occurs in discrete regions of the adult mammalian brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. Emerging evidence suggests that various epigenetic mechanisms play important roles in fine-tuning and coordinating gene expression during adult neurogenesis. Here we review recent progress in our understanding of various epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, as well as cross-talk among these mechanisms, in regulating different aspects of adult mammalian neurogenesis.

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