Get access
Liver International

Normal enhanced liver fibrosis (ELF) values in apparently healthy subjects undergoing a health check-up and in living liver donors in South Korea

Authors

  • Eun Jin Yoo,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
    • Both authors contributed equally to this work.
  • Beom Kyung Kim,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
    • Both authors contributed equally to this work.
  • Seung Up Kim,

    Corresponding author
    1. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    • Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Jun Yong Park,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    3. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Do Young Kim,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    3. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Sang Hoon Ahn,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    3. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    4. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Kwang-Hyub Han,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    3. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    4. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Chae Yoon Chon,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    3. Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author
  • Hyon-Suk Kim

    1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    Search for more papers by this author

Correspondence

Seung Up Kim, MD

Department of Internal Medicine, Yonsei University College of Medicine

50 Yonsei-ro, Seodaemun–gu, Seoul 120–752, South Korea

Tel: 82 2 2228 1982

Fax: 82 2 393 6884

e-mail: ksukorea@yuhs.ac

Abstract

Background

The enhanced liver fibrosis (ELF) value is a non-invasive serum marker used for assessing liver fibrosis in chronic liver disease. To use the ELF value for the purpose of screening the general population and selecting subpopulations at high risk, it is important to know the normal range of ELF values as a prerequisite.

Aims

We aimed to define the normal range of ELF values by recruiting apparently healthy subjects and investigating factors influencing ELF values in subjects with minimal fibrotic burden.

Methods

ELF values were determined in a cohort of healthy subjects who underwent a health check-up and in healthy living liver donors who were screened for transplantation. None of subjects suffered from chronic heart disease, diabetes mellitus, metabolic syndrome, hepatitis B, hepatitis C, or human immunodeficiency virus infection, systemic autoimmune disease or liver dysfunction.

Results

Among 183 subjects analyzed, the normal ELF 5th through 95th percentile range was 5.95–8.73. Body mass index (= 0.014) and male gender (= 0.015) showed significant positive correlations with ELF value, whereas age did not. In multivariate linear regression analysis, platelet count was identified as the only independent factor influencing the ELF value (β=−0.006, = 0.016). When considering the difference in ELF values between genders, the normal range of men was defined to be 6.72–8.93, this was slightly higher than that of women, 5.69–8.67.

Conclusions

We identified the normal range of ELF values and found that it can be significantly influenced by platelet count even in the healthy population.

Get access to the full text of this article

Ancillary