Chapter 4.2 Crystallization of membrane proteins

Crystallography of biological macromolecules

First Online Edition (2006)

Part 4. Crystallization

  1. H. Michel

Published Online: 1 JAN 2006

DOI: 10.1107/97809553602060000661

International Tables for Crystallography

International Tables for Crystallography

How to Cite

Michel, H. 2006. Crystallization of membrane proteins. International Tables for Crystallography. F:4:4.2:94–99.

Author Information

  1. Max‐Planck‐Institut für Biophysik, Heinrich‐Hoffmann‐Strasse 7, D‐60528 Frankfurt/Main, Germany

Publication History

  1. Published Online: 1 JAN 2006



The crystallization of membrane proteins is described. The topics covered include the principles of membrane‐protein crystallization, general properties of detergents relevant to membrane‐protein crystallization, the ‘small amphiphile concept’, membrane‐protein crystallization with the help of antibody Fv fragments and membrane‐protein crystallization using cubic bicontinuous lipidic phases. General recommendations on crystallizing membrane proteins are provided, and membrane proteins with known structures and potentially useful detergents are tabulated.


  • antibody Fv fragments in crystallization of membrane proteins;
  • crystallization;
  • cubic bicontinuous lipidic phases;
  • detergents;
  • membrane proteins;
  • small amphiphile concept