Chapter 10.3 Radiation damage

Crystallography of biological macromolecules

Second Online Edition (2012)

Part 10. Cryocrystallography

  1. E. F. Garman

Published Online: 14 APR 2012

DOI: 10.1107/97809553602060000829

International Tables for Crystallography

International Tables for Crystallography

How to Cite

Garman, E. F. 2012. Radiation damage. International Tables for Crystallography. F:10:10.3:256–261.

Author Information

  1. Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, England

Publication History

  1. Published Online: 14 APR 2012



Radiation damage and its effects on diffraction data and the biological information obtained from macromolecular structures has re‐emerged as a concern for crystallographers as ever more intense synchrotron‐produced X‐ray beams become available. Cryocrystallographic techniques, where crystals are cooled to around 100 K, are no longer enough, and there is also a resurgence of interest in room‐temperature data collection where damage is swift. The current status of our knowledge and understanding of radiation damage in macromolecular crystallography is summarized.


  • radiation damage;
  • cryocrystallography