BioEssays

Cover image for Vol. 39 Issue 6

Edited By: Andrew Moore

Online ISSN: 1521-1878

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Volume 39, Issue 6, June 2017


Cell reintegration: Stray epithelial cells make their way home

Cell reintegration: Stray epithelial cells make their way home

Tyler J. Wilson, Dan T. Bergstralh*

Isolated epithelial cells can reintegrate into an epithelial layer, and ongoing work suggests that this process is driven by adhesion factors that line cell-borders. While reintegration has clear implications for tissue development and maintenance, the possibility that it also participates in cancer progression remains to be explored.

BioEssays2017, 39, No. 6, 0 [Insights & Perspectives]

Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer

Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer

Stine F. Pedersen*, Ivana Novak, Frauke Alves, Albrecht Schwab, Luis A. Pardo*

Cells in organs performing net acid-base transport, like the pancreatic ductal and gastric epithelia, survive in an extraordinarily large and variable extracellular pH gradient. This renders epithelial and stromal cells pre-adapted to the heterogeneous extracellular pH in the tumor microenvironment and may thereby contribute to the development of epithelial cancers.

BioEssays2017, 39, No. 6, 0 [Insights & Perspectives]

Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal

Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal

Ido Livneh, Yelena Kravtsova-Ivantsiv, Ori Braten, Yong Tae Kwon, Aaron Ciechanover*

Polyubiquitination has been regarded as the hallmark signal for proteasomal degradation. Employing a systematic screen in both human and yeast cells, numerous proteasomal substrates were shown to be degraded following monoubiquitination, suggesting that this modification is more widespread than previously thought. Importantly, these substrates demonstrate distinct structural and functional characteristics.

BioEssays2017, 39, No. 6, 0 [Prospects & Overviews]

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