BioEssays

Cover image for Vol. 39 Issue 8

Edited By: Andrew Moore

Online ISSN: 1521-1878

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Volume 39, Issue 8, August 2017


Multisensory neural integration of chemical and mechanical signals

Multisensory neural integration of chemical and mechanical signals

Juan Antonio Sánchez-Alcañiz, Richard Benton*

Although neuroscientists often study individual sensory modalities independently of all others, animals naturally assimilate diverse types of environmental cues to respond with an appropriate behavior. Recent work has revealed how multisensory integration of chemical and mechanical stimuli can occur through the use of common sensory receptor families, organs and circuitry.

BioEssays2017, 39, No. 8, 0 [Prospects & Overviews]

Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer

Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer

Di Zhao, Ronald A. DePinho*

We summarize recent work exploring a novel conceptual approach termed “synthetic essentiality” as a means for targeting tumor suppressor gene deficiencies in cancer. Synthetic essentiality expands the existing concepts for therapeutic strategies, including oncogene addiction, synthetic, and collateral lethality, to provide a framework for the discovery of cancer-specific vulnerabilities.

BioEssays2017, 39, No. 8, 0 [Prospects & Overviews]

Phototoxicity in live fluorescence microscopy, and how to avoid it

Phototoxicity in live fluorescence microscopy, and how to avoid it

Jaroslav Icha, Michael Weber*, Jennifer C. Waters, Caren Norden*

Phototoxicity during live fluorescence microscopy is a frequent side effect of excess illumination that can influence data quality. Samples can be affected by phototoxicity even before it becomes obvious from their morphology. In this review, we explore how to mitigate and control for phototoxicity to collect reliable quantitative imaging data.

BioEssays2017, 39, No. 8, 0 [Prospects & Overviews]

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