BioEssays

Cover image for Vol. 39 Issue 5

Edited By: Andrew Moore

Online ISSN: 1521-1878

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Volume 39, Issue 4, April 2017


Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss

Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss

Tara E. Tracy*, Li Gan*

Taupathies are age-related neurodegenerative diseases, including Alzheimer's disease, that are characterized by accumulation of tau protein in the brain and cognitive decline. We hypothesize that enhanced levels of abnormally acetylated tau in tauopathy disrupts the KIBRA-dependent mechanisms that regulate plasticity at synapses leading to memory loss.

BioEssays 10.1002/bies.201600224 [Insights & Perspectives]

The agotrons: Gene regulators or Argonaute protectors?

The agotrons: Gene regulators or Argonaute protectors?

Lotte V. W. Stagsted, Iben Daugaard, Thomas B. Hansen*

Agotrons are full-length, debranched introns associating with Argonaute (Ago) proteins in a Drosha- and Dicer-independent manner. The ensuing question is whether agotrons are occupying Ago to regulate target gene expression, or to protect Ago-proteins from degradation and avoid loading of aberrant RNA in Ago.

BioEssays 10.1002/bies.201600239 [Insights & Perspectives]

Capitalizing on disaster: Establishing chromatin specificity behind the replication fork

Capitalizing on disaster: Establishing chromatin specificity behind the replication fork

Srinivas Ramachandran, Kami Ahmad, Steven Henikoff*

Disruption of chromatin by passage of the replication fork offers a window of opportunity for the rebinding of transcription factors (TFs) genome-wide. However, the rapid deposition of nucleosomes behind the replication fork and the ensuing competition between nucleosomes and TFs would enforce sensitivity to TF concentration and binding site specificity.

BioEssays 10.1002/bies.201600150 [Prospects & Overviews]

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