Journal of Bone and Mineral Research

Cover image for Vol. 32 Issue 6

Edited By: Juliet E Compston

Impact Factor: 6.284

ISI Journal Citation Reports © Ranking: 2016: 14/138 (Endocrinology & Metabolism)

Online ISSN: 1523-4681

Associated Title(s): JBMR Plus

Featured

  • Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential

    Connexin43 Mutant Patient‐Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential

    Cx43 expression is reduced upon the onset of in vitro osteogenic differentiation. Representative immunofluorescent confocal micrographs of Cx43 (green) during osteogenesis in control and ODDD iPSCs. Nuclei (Hoechst, blue) and actin (phalloidin, red) are used to delineate cell shape and morphology. Inset, Cx43 only immunofluorescence. Scale bars = 50 μm.

  • Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone

    Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone

    Collagen fibril diameter. (A) Representative electron microscopy images of collagen fibrils, extracted from femoral bones of fl/fl Cre+ mice and control littermates, are shown from paired samples. (B, C) Quantification of the diameters of collagen fibrils are shown from two littermate pairs of control and mutant mice. From 87 to 158 individual fibrils were measured in 30 to 37 separate image fields from each bone.

  • A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen

    A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen

    Cellular localization of LH2 and BiP. Intracellular immunolocalization of LH2 and BiP in human fibroblasts. (A–F) LH2 is shown in red and FKBP65 in green. (G–I) BiP is shown in green and HSP47 in red. Control cells (A, D, and G); FKBP10-/- cells (B, E, and H); and HSP47M237T/M237T cells (C, F, and I). LH2 colocalized with FKBP65 in the ER (D–F), including within abnormal vesicles in mutant cells (arrows). BiP colocalized partially with HSP47 in the ER but not in either the Golgi or abnormal vesicles (arrow). Nuclei were stained with DAPI (in blue). Green arrows identify the Golgi compartment.

  • Spinal Loading Patterns From Biomechanical Modeling Explain the High Incidence of Vertebral Fractures in the Thoracolumbar Region

    Spinal Loading Patterns From Biomechanical Modeling Explain the High Incidence of Vertebral Fractures in the Thoracolumbar Region

    Image of the four spine models, each with a different spine curvature, used in this study. (A) The model with no kyphosis (TK = 0 degrees, LL = −24.8 degrees), (B) the low kyphosis model (TK = 26 degrees, LL = –34.3 degrees), (C) the average kyphosis model (TK = 50 degrees, LL = –43 degrees), and (D) the high kyphosis model (TK = 74 degrees, LL = –51.7 degrees). TK = thoracic kyphosis; LL = lumbar lordosis.

  • Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma

    Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma

    Three dimensional patient CT reconstructions renderings. (A) Pretreatment (B) After completion of melphalan 200mg/m2 based autologous stem cell transplant.

  • Understanding Bone Strength Is Not Enough

    Understanding Bone Strength Is Not Enough

    The contributions to whole-bone fracture from tissue material properties are illustrated with circles. (Left) A common misperception is that tissue material strength, fracture toughness, and fatigue strength are independent and that tissue strength is much more important. (Right) In reality the three material properties have interdependencies that are represented by the overlap in the figures. For example, a measure of tissue material strength is influenced by fracture toughness and fatigue strength (the regions overlapping with other circles).

  • Connexin43 Mutant Patient‐Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential
  • Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone
  • A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen
  • Spinal Loading Patterns From Biomechanical Modeling Explain the High Incidence of Vertebral Fractures in the Thoracolumbar Region
  • Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma
  • Understanding Bone Strength Is Not Enough

Just Published Articles

  1. Immediate Initiation of Antiretroviral Therapy for HIV Infection Accelerates Bone Loss Relative to Deferring Therapy: Findings from the START Bone Mineral Density Substudy, a Randomized Trial

    Jennifer F Hoy, Birgit Grund, Mollie Roediger, Ann V Schwartz, John Shepherd, Anchalee Avihingsanon, Sharlaa Badal-Faesen, Stephane de Wit, Simone Jacoby, Alberto La Rosa, Sanjay Pujari, Mauro Schechter, David White, Nicole Wyman Engen, Kristine Ensrud, Peer D Aagaard, Andrew Carr and for the INSIGHT START Bone Mineral Density Substudy Group

    Version of Record online: 26 JUN 2017 | DOI: 10.1002/jbmr.3183

  2. Hypermineralization and High Osteocyte Lacunar Density in Osteogenesis Imperfecta Type V Bone Indicate Exuberant Primary Bone Formation

    Stéphane Blouin, Nadja Fratzl-Zelman, Francis H Glorieux, Paul Roschger, Klaus Klaushofer, Joan C Marini and Frank Rauch

    Version of Record online: 26 JUN 2017 | DOI: 10.1002/jbmr.3180

  3. Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development

    Takamitsu Maruyama, Ming Jiang, Alycia Abbott, H-M Ivy Yu, Qirong Huang, Magdalena Chrzanowska-Wodnicka, Emily I Chen and Wei Hsu

    Version of Record online: 26 JUN 2017 | DOI: 10.1002/jbmr.3171

  4. Greater Gains in Spine and Hip Strength for Romosozumab Compared With Teriparatide in Postmenopausal Women With Low Bone Mass

    Tony M Keaveny, Daria B Crittenden, Michael A Bolognese, Harry K Genant, Klaus Engelke, Beatriz Oliveri, Jacques P Brown, Bente L Langdahl, Chris Yan, Andreas Grauer and Cesar Libanati

    Version of Record online: 26 JUN 2017 | DOI: 10.1002/jbmr.3176

  5. You have free access to this content
    Tethering Formation to Resorption: Reversal Revisited

    David W Dempster

    Version of Record online: 26 JUN 2017 | DOI: 10.1002/jbmr.3169

More

JBMR's 30th Anniversary: Cause for Celebration

eCompendia Series

Celebrate the Journal of Bone and Mineral Research 30th Anniversary! Browse our new timeline and see key milestones over the years!

Read the Editorial by Editor-in-Chief Juliet Compston right here

Announcing

JBMR® Announces Workflow Changes and Author Guidelines Updates

In response to rising concerns over the reproducibility of biomedical research, the author guidelines and submission procedures for the Journal of Bone and Mineral Research’s (JBMR®) have recently been updated. These updates affect the submission workflow of author forms required for peer review and publication, as detailed below:


ARRIVE: Authors submitting research on animal studies are now required to complete an adapted ARRIVE (Animals in Research: Reporting In Vivo Experiments) checklist at submission.


CONSORT: Authors of manuscripts reporting results of clinical trials are now required to upload the CONSORT checklist at submission.


STROBE: Authors of manuscripts reporting results of human observational case-control, cohort, or cross-sectional studies are now required to upload the STROBE checklist at submission.


Author Agreement: The conflict of interest (COI) and copyright transfer (CTA) portions of the current Author Agreement can now be completed electronically as a web form, eliminating the need for authors to print, scan and upload a PDF form upon submission.


• COI information will be collected during submission via an online questionnaire on ScholarOne.


• The CTA will be completed at manuscript acceptance: If a manuscript is accepted for publication, the corresponding author will receive an e-mail prompt to log in to Author Services. Author Services is a Wiley web application that provides production tracking, as well as other resources for authors. From this site, corresponding authors can complete the CTA on behalf of all authors on the paper.

eCompendia

eCompendia Series

eCompendia – special issues of recent JBMR® articles on hot topics

eCompendia bring together recently published JBMR® articles on topical issues. Specific topics are selected for each eCompendium to provide the reader with an easy-to-access update that brings together original research articles in the chosen area.

Examples of topics addressed in recent eCompendia include Kidney Disease and Bone, Sclerostin: Preclinical and Clinical Studies and Genetics of Osteogenesis Imperfecta.

Click here for more


Osteoporosis: The Treatment Gap


ASBMR 2016 Publications Workshop Presentation

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