Journal of Bone and Mineral Research

Cover image for Vol. 32 Issue 11

Edited By: Juliet E Compston

Impact Factor: 6.284

ISI Journal Citation Reports © Ranking: 2016: 15/138 (Endocrinology & Metabolism)

Online ISSN: 1523-4681

Associated Title(s): JBMR Plus

Featured

  • Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting

    Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting

    Example of fracture that was characterized as an AFF by both 2010 and 2013 criteria.

  • Longitudinal Adaptations of Bone Mass, Geometry, and Metabolism in Adolescent Male Athletes: The PRO-BONE Study

    Longitudinal Adaptations of Bone Mass, Geometry, and Metabolism in Adolescent Male Athletes: The PRO‐BONE Study

    Differences (%) in adjusted bone geometry estimates and trabecular bone score at the femoral neck and lumbar spine regions between the groups after 1 year of sports specific training. The results are adjusted for age, height, region specific lean mass, MVPA and baseline values of bone geometry estimates. CSMI: Cross sectional moment of inertia, CSA: cross-sectional area, TBS: Trabecular Bone score, Z: Section modulus. The figures represent unadjusted results of participants of the same age, height and training hours. Significance at * p < 0.05 and **p < 0.01.

  • Multimodality Image-Guided Cryoablation for Inoperable Tumor-Induced Osteomalacia

    Multimodality Image‐Guided Cryoablation for Inoperable Tumor‐Induced Osteomalacia

    Localization studies for subject 1. (A) FDG-PET coronal (A1) and sagittal image (A2) of torso showing artifact from rod (orange arrow) and culprit tumor (white arrow). (B) Coronal view of FDG-PET scan of left proximal femur localizing the lesion (white arrow), femoral head (yellow arrow), and rod (orange arrow). (C) Axial view of FDG-PET/CT fusion imaging of left proximal femur localizing the lesion: white arrows point to the tumor, yellow arrow points to the femoral shaft, and orange arrow points to the side plate. (D) Selective venous sampling for intact FGF23. There was a significant step-up in intact FGF23 concentration as the suspected tumor venous drainage was approached anatomically. (E) CT scan sagittal view torso showing sternal collapse (white arrow), kyphosis (orange arrow), vertebral compression fractures (yellow arrow), and restrictive lung disease (asterisk).

  • Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor

    Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor

    Differential expression of proteins from various signaling pathways in control and mutant mandibular incisors. (A–P) Immunofluorescence staining showed differential expression of numerous proteins in the liCL and laCL regions. pMEK (A,B), pSMAD (E,F), NICD (I,J), and CLDN1 (M,N) were all upregulated in mutant liCL (white arrowheads). In the laCL, only pMEK (C,D) and pSMAD (G,H) appeared to be upregulated in mutants; NICD (K,L) and CLDN1 (O,P) remained unchanged.

  • Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation

    Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation

    Gain-of-function mutation of FGFR2 promotes recruitment and proliferation of bone marrow stromal cells and osteoblast proliferation and differentiation after BMX. (A) H&E staining of paraffin-embedded tibial sections at 4 days after BMX. Black box regions are magnified on the right. (B) Proliferation of bone marrow stromal cells at 4 days after BMX measured by EdU incorporation. Proliferating stromal cells were EdU-positive cells (red), and nuclei were stained as blue (DAPI). (C) Representative images of EdU incorporation assay at 1 week after BMX. Right panels show magnified views of double staining with Runx2. Yellow arrows indicate proliferating osteoblasts. (D) Quantifications of the proliferating osteoblasts (n = 3). (E) Immunohistochemistry (IHC) staining for Runx2 (left) and osteocalcin (right) at 1 week after BMX. B = bone; OB = osteoblast. Values are the mean ± SD. *p < 0.05 compared with WT mice. Scale bar = 50 μm.

  • Overexpression of GαS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality

    Overexpression of GαS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality

    HOM-GS mice show evidence of dysregulated bone remodeling with increased osteoblast function and ectopic osteoclast activity. (A) Representative images of trabecular bone at the proximal metaphysis of the tibia stained with Goldner's trichrome, labeled with calcein green, stained with TRAP, and stained with toluidine blue. Scale bars = 50 µm. (B) Representative backscatter electron microscopy images of trabecular bone at the proximal metaphysis of the tibia. Gray signifies lower density whereas white signifies higher density. (C) Representative images of cortical bone at the mid-diaphysis of the tibia stained with TRAP. Scale bars = 100 µm. (D) Representative images of the growth plate of the proximal tibia stained with Goldner's trichrome. WT and HOM-GS mice were 9 weeks of age.

  • Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting
  • Longitudinal Adaptations of Bone Mass, Geometry, and Metabolism in Adolescent Male Athletes: The PRO‐BONE Study
  • Multimodality Image‐Guided Cryoablation for Inoperable Tumor‐Induced Osteomalacia
  • Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor
  • Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation
  • Overexpression of GαS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality

Just Published Articles

  1. Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension

    Steven R Cummings, Serge Ferrari, Richard Eastell, Nigel Gilchrist, Jens-Erik Beck Jensen, Michael McClung, Christian Roux, Ove Törring, Ivo Valter, Andrea T Wang and Jacques P Brown

    Version of Record online: 22 NOV 2017 | DOI: 10.1002/jbmr.3337

  2. You have free access to this content
    How important is vitamin D for calcium homeostasis during pregnancy and lactation?

    Geert Carmeliet and Roger Bouillon

    Accepted manuscript online: 22 NOV 2017 09:55AM EST | DOI: 10.1002/jbmr.3344

  3. Dietary Advanced Glycation End Products have Sex-and Age Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice

    Svenja Illien-Jünger, Paolo Palacio-Mancheno, William F. Kindschuh, Xue Chen, Grazyna E Sroga, Deepak Vashishth and James C Iatridis

    Accepted manuscript online: 21 NOV 2017 11:40AM EST | DOI: 10.1002/jbmr.3321

  4. Hypophosphatemia, Severe Bone Pain, Gait Disturbance, and Fatigue Fractures After Iron Substitution in Inflammatory Bowel Disease: A Case Report

    Johann Bartko, Paul Roschger, Shahin Zandieh, Attila Brehm, Jochen Zwerina and Klaus Klaushofer

    Version of Record online: 21 NOV 2017 | DOI: 10.1002/jbmr.3319

  5. Changing of the Guard

    Version of Record online: 21 NOV 2017 | DOI: 10.1002/jbmr.3311

More

Design Enhancements for JBMR Online

Design Enhancements for JBMR online

News

JBMR® Announces Workflow Changes and Author Guidelines Updates

In response to rising concerns over the reproducibility of biomedical research, the author guidelines and submission procedures for the Journal of Bone and Mineral Research’s (JBMR®) have recently been updated. These updates affect the submission workflow of author forms required for peer review and publication, as detailed below:


ARRIVE: Authors submitting research on animal studies are now required to complete an adapted ARRIVE (Animals in Research: Reporting In Vivo Experiments) checklist at submission.


CONSORT: Authors of manuscripts reporting results of clinical trials are now required to upload the CONSORT checklist at submission.


STROBE: Authors of manuscripts reporting results of human observational case-control, cohort, or cross-sectional studies are now required to upload the STROBE checklist at submission.


Author Agreement: The conflict of interest (COI) and copyright transfer (CTA) portions of the current Author Agreement can now be completed electronically as a web form, eliminating the need for authors to print, scan and upload a PDF form upon submission.


• COI information will be collected during submission via an online questionnaire on ScholarOne.


• The CTA will be completed at manuscript acceptance: If a manuscript is accepted for publication, the corresponding author will receive an e-mail prompt to log in to Author Services. Author Services is a Wiley web application that provides production tracking, as well as other resources for authors. From this site, corresponding authors can complete the CTA on behalf of all authors on the paper.

eCompendia


Osteoporosis: The Treatment Gap


Special Content from JBMR

Graphical Abstracts

2017 Publications Workshop

Checklists to help you get published

SEARCH

SEARCH BY CITATION