Journal of Bone and Mineral Research

Cover image for Vol. 32 Issue 12

Edited By: Juliet E Compston

Impact Factor: 6.284

ISI Journal Citation Reports © Ranking: 2016: 15/138 (Endocrinology & Metabolism)

Online ISSN: 1523-4681

Associated Title(s): JBMR Plus

Featured

  • The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent

    The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent

    Activin A is required for sustained growth of nascent HO lesions. (A) Mean (± standard error [SE]) total HO volume time courses after either 25 mg/kg REGN2477 (anti-Activin A antibody) or 25 mg/kg REGN1945 (isotype control antibody) at days 21, 28, and 42 after model initiation. Treatment was started at day 21 (baseline). (B) Change in total HO volume between days 21 and 42. (C) Example of HO burden in an FOP mouse before and after 21 days of REGN2477 treatment, where the total HO volume decreased from baseline. (D) Example of HO burden in an FOP mouse before and after 21 days of REGN1945 treatment, where the total HO volume increased from baseline.

  • Mast Cells Are Critical Regulators of Bone Fracture–Induced Inflammation and Osteoclast Formation and Activity

    Mast Cells Are Critical Regulators of Bone Fracture–Induced Inflammation and Osteoclast Formation and Activity

    Presence of mast cells (MCs) during fracture healing. MCs were identified using an anti-MC protease-7 antibody in longitudinal sections of the fracture callus of MC-competent mice (upper two rows) and by using MC reporter mice (lower row), in which osteoclasts were additionally stained using an anti-cathepsin K antibody, at days 3 (A–C), 7 (D–F), 14 (G–I), and 23 (J–L). Arrowheads indicate MCs; arrows indicate osteoclasts. BM = bone marrow; CB = cortical bone; FG = fracture gap; PC = periosteal callus. Scale bars = 500 μm (upper row) and 50 μm (lower two rows).

  • PLS3 Deletions Lead to Severe Spinal Osteoporosis and Disturbed Bone Matrix Mineralization

    PLS3 Deletions Lead to Severe Spinal Osteoporosis and Disturbed Bone Matrix Mineralization

    Goldner's trichrome-stained histological bone section is showing a trabecular bone feature with increased osteoid deposition (red, *) covered with lining cells (empty arrows) on one side and with osteoblasts on the other side (full arrows). Mineralized bone matrix (white cross) is stained by green color.

  • Long-Term Effects of Severe Burn Injury on Bone Turnover and Microarchitecture

    Long‐Term Effects of Severe Burn Injury on Bone Turnover and Microarchitecture

    High-resolution peripheral quantitative computed tomography (HR-pQCT) changes at the radius (top) and at the tibia (bottom) of a representative burn patient aged 42 years at the end of the early phase and at month 24 after thermal injury (mechanism of injury: flame; total body surface area of burn injury (TBSA) 45%, full-thickness burn injury). Influences and pathomechanisms illustrate the impact of a thermal trauma on bone turnover and microarchitecture, based on the findings of this study and current literature.

  • Impact Microindentation: Consistency of Serial Measurements and Alterations in Patients With Paget's Disease of the Tibia

    Impact Microindentation: Consistency of Serial Measurements and Alterations in Patients With Paget's Disease of the Tibia

    Characteristic radiographic features of the tibias of two patients with Paget's disease of bone included in the study.

  • How Basic Science Discoveries Have Shaped the Treatment of Bone and Mineral Disorders

    How Basic Science Discoveries Have Shaped the Treatment of Bone and Mineral Disorders

    Osteoclast differentiation and bone resorption is stimulated by RANKL in combination with MCSF but blocked by OPG. Denosumab inhibits bone resorption by neutralizing RANKL. Mature osteoclasts degrade bone matrix by secreting CATK onto the bone surface but this is inhibited by odanacatib. Romosozumab stimulates bone formation by neutralizing SOST, which antagonizes the stimulatory effects of Wnt on the LRP-beta-catenin pathway. KRN23 corrects hypophosphatemic rickets by neutralizing FGF23, a master regulator of renal phosphate excretion. MCSF = macrophage colony stimulating factor; OPG = osteoprotegerin; CATK = cathepsin K; SOST = sclerostin.

  • The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent
  • Mast Cells Are Critical Regulators of Bone Fracture–Induced Inflammation and Osteoclast Formation and Activity
  • PLS3 Deletions Lead to Severe Spinal Osteoporosis and Disturbed Bone Matrix Mineralization
  • Long‐Term Effects of Severe Burn Injury on Bone Turnover and Microarchitecture
  • Impact Microindentation: Consistency of Serial Measurements and Alterations in Patients With Paget's Disease of the Tibia
  • How Basic Science Discoveries Have Shaped the Treatment of Bone and Mineral Disorders

Just Published Articles

  1. Specific Modulation of Vertebral Marrow Adipose Tissue by Physical Activity

    Daniel L Belavy, Matthew J Quittner, Nicola D Ridgers, Adnan Shiekh, Timo Rantalainen and Guy Trudel

    Version of Record online: 16 JAN 2018 | DOI: 10.1002/jbmr.3357

  2. Positive-feedback regulation of subchondral H-type vessel formation by chondrocyte promotes osteoarthritis development in mice

    Jiansen Lu, Haiyan Zhang, Daozhang Cai, Chun Zeng, Pinglin Lai, Yan Shao, Hang fang, Delong Li, Jiayao Ouyang, Chang Zhao, Denghui Xie, Bin Huang, Jian Yang, Yu Jiang and Xiaochun Bai

    Accepted manuscript online: 12 JAN 2018 04:11PM EST | DOI: 10.1002/jbmr.3388

  3. Genetic and molecular insights into genotype-phenotype relationships in osteopathia striata with cranial sclerosis (OSCS) through the analysis of novel mouse Wtx mutant alleles

    Glenda Comai, Agnès Boutet, Kristina Tanneberger, Filippo Massa, Ana-Sofia Rocha, Aurelie Charlet, Clara Panzolini, Fariba Jian Motamedi, Robert Brommage, Wolfgang Hans, Thomas Funck-Brentano, Martin Hrabe de Angelis, Christine Hartmann, Martine Cohen-Solal, Jürgen Behrens and Andreas Schedl

    Accepted manuscript online: 12 JAN 2018 04:10PM EST | DOI: 10.1002/jbmr.3387

  4. Effects of Teriparatide Compared with Risedronate on the Risk of Fractures in Subgroups of Postmenopausal Women with Severe Osteoporosis: The VERO Trial

    Piet Geusens, Fernando Marin, David L. Kendler, Luis A. Russo, Cristiano A.F. Zerbini, Salvatore Minisola, Jean Jacques Body, Eric Lespessailles, Susan L. Greenspan, Alicia Bagur, Jan J. Stepan, Péter Lakatos, Enrique Casado, Rüdiger Moericke, Pedro López-Romero and Astrid Fahrleitner-Pammer

    Accepted manuscript online: 12 JAN 2018 04:05PM EST | DOI: 10.1002/jbmr.3384

  5. A History of Pivotal Advances in Clinical Research into Bone and Mineral Diseases

    Steven R Cummings and Richard Eastell

    Version of Record online: 12 JAN 2018 | DOI: 10.1002/jbmr.3353

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Design Enhancements for JBMR Online

Design Enhancements for JBMR online

News

JBMR® Announces Workflow Changes and Author Guidelines Updates

In response to rising concerns over the reproducibility of biomedical research, the author guidelines and submission procedures for the Journal of Bone and Mineral Research’s (JBMR®) have recently been updated. These updates affect the submission workflow of author forms required for peer review and publication, as detailed below:


ARRIVE: Authors submitting research on animal studies are now required to complete an adapted ARRIVE (Animals in Research: Reporting In Vivo Experiments) checklist at submission.


CONSORT: Authors of manuscripts reporting results of clinical trials are now required to upload the CONSORT checklist at submission.


STROBE: Authors of manuscripts reporting results of human observational case-control, cohort, or cross-sectional studies are now required to upload the STROBE checklist at submission.


Author Agreement: The conflict of interest (COI) and copyright transfer (CTA) portions of the current Author Agreement can now be completed electronically as a web form, eliminating the need for authors to print, scan and upload a PDF form upon submission.


• COI information will be collected during submission via an online questionnaire on ScholarOne.


• The CTA will be completed at manuscript acceptance: If a manuscript is accepted for publication, the corresponding author will receive an e-mail prompt to log in to Author Services. Author Services is a Wiley web application that provides production tracking, as well as other resources for authors. From this site, corresponding authors can complete the CTA on behalf of all authors on the paper.

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