Journal of Bone and Mineral Research

Cover image for Vol. 31 Issue 8

Edited By: Juliet E Compston

Impact Factor: 5.622

ISI Journal Citation Reports © Ranking: 2015: 15/131 (Endocrinology & Metabolism)

Online ISSN: 1523-4681

Featured

  • Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)-G610C Mouse Model of Osteogenesis Imperfecta

    Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)‐G610C Mouse Model of Osteogenesis Imperfecta

    Skeletal staining of newborn pups with Alizarin red (mineral) and Alcian blue (glycosaminoglycans). (A–D) WT, (E–H) severely affected Het, and (I–L) Hom. (A, E, I) Skulls and enlarged images of separated parietal bones. (B, F, J) Rib cages. (C, G, K) Scapulas; each in two projections to show deformities. (D, H, L) Femurs, tibias, and fibulas; sharp bending of Hom femurs illustrates severe long bone deformities. Separation of hind leg bones was an artifact of sample preparation, resulting from overdigestion of much thinner (versus WT and Het) ligaments in Hom neonates by KOH during the clearing step of skeletal staining. Each set is from the same mouse. Contrast was digitally enhanced in individual images.

  • Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study

    Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study

    Representative H&E-stained images from maxilla of all groups and quantification of the histological findings. (A, C, E, G) Healthy and (B, D, F, H) diseased site of vehicle, ZA, CIA, and CIA-ZA mice. Original magnification ×5. (B1, D1, F1, H1) Histological appearance of periodontal and alveolar crest area of maxillae in magnified views of the diseased site. Original magnification ×10. Red arrows point to marginal gingival epithelium; turquoise arrows show alveolar crest; yellow arrows indicate osteonecrotic areas; and areas of bone exposure are flagged by green arrows. (I–K) Quantification of the histological findings: The shortest epithelial-crest distance, percentage of osteocytic lacunae, and percentage of areas of osteonecrosis were measured, respectively. +Statistically significant difference from indicated groups, p < 0.0001. **Statistically significant difference from indicated groups, p < 0.001. *Statistically significant difference from indicated groups, p < 0.05. Differences among groups were calculated by two-way ANOVA and between groups by Student's t test. Data represent the mean ± SEM.

  • Finite Element Analysis of Denosumab Treatment Effects on Vertebral Strength in Ovariectomized Cynomolgus Monkeys

    Finite Element Analysis of Denosumab Treatment Effects on Vertebral Strength in Ovariectomized Cynomolgus Monkeys

    Cut-out views of the continuum-type finite element models (300-μm-sized elements) of (Top) the T12 vertebral body from a vehicle-treated monkey, and (Bottom) a denosumab-treated monkey. (Left) The distribution of element-level volumetric BMD (darker colors denote lower values of BMD; blue is a virtual layer of plastic). (Center) Virtually crushed models of the bones showing the overall deformation and failure patterns of the models at each respective failure load (colored overlay depicts plastic strain; blue is a virtual layer of plastic; deformations are magnified). (Right) For illustrative purposes, the deformation and failure patterns of the models are also shown for both bones after loading to the same uniform compressive force of 2300 newtons (N) (the mean strength of all the OVX-Vehicle specimens).

  • Incidence of Atypical Femur Fractures in Cancer Patients: The MD Anderson Cancer Center Experience

    Incidence of Atypical Femur Fractures in Cancer Patients: The MD Anderson Cancer Center Experience

    Progression of an atypical femur fracture in a cancer patient. (A) Femur shaft showing the lateral beak. (B) Complete atypical femur fracture occurs. (C) Postsurgical atypical femur fracture with intramedullary nailing and callus formation.

  • Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men

    Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men

    Depiction of the cortical bone in the cross-sectional slices of the FN and the TR as defined with QCTpro in the process of the image analysis. The upper quadrants of the TR and FN showed the highest LTI in a preceding statistical analysis on 20 men and were used to define the volume of local cortical thinning.

  • Differential Effects of Teriparatide and Zoledronic Acid on Bone Mineralization Density Distribution at 6 and 24 Months in the SHOTZ Study

    Differential Effects of Teriparatide and Zoledronic Acid on Bone Mineralization Density Distribution at 6 and 24 Months in the SHOTZ Study

    Examples of qBEI images of cancellous bone from paired biopsy samples. qBEI images from one TPTD- and one ZOL-treated patient; brighter pixels indicate higher mineral content. For TPTD, low mineralized bone packets (blue arrows) at both 6 and 24 months suggest recently formed bone matrix. For ZOL, at 6 months bone packets with the lowest mineral content (orange arrows) have greater mineralization versus TPTD treatment. Scale bars = 250 μm.

  • Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)‐G610C Mouse Model of Osteogenesis Imperfecta
  • Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study
  • Finite Element Analysis of Denosumab Treatment Effects on Vertebral Strength in Ovariectomized Cynomolgus Monkeys
  • Incidence of Atypical Femur Fractures in Cancer Patients: The MD Anderson Cancer Center Experience
  • Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men
  • Differential Effects of Teriparatide and Zoledronic Acid on Bone Mineralization Density Distribution at 6 and 24 Months in the SHOTZ Study

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eCompendia – special issues of recent JBMR® articles on hot topics

eCompendia bring together recently published JBMR® articles on topical issues. Specific topics are selected for each eCompendium to provide the reader with an easy-to-access update that brings together original research articles in the chosen area.

Examples of topics addressed in recent eCompendia include Kidney Disease and Bone, Sclerostin: Preclinical and Clinical Studies and Genetics of Osteogenesis Imperfecta.

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ASBMR 2015 Publications Workshop Presentation

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JBMR's 30th Anniversary: Cause for Celebration

30anniversary

Read the Editorial by Editor-in-Chief Juliet Compston right here

Announcing

JBMR® Announces Workflow Changes and Author Guidelines Updates

In response to rising concerns over the reproducibility of biomedical research, the author guidelines and submission procedures for the Journal of Bone and Mineral Research’s (JBMR®) have recently been updated. These updates affect the submission workflow of author forms required for peer review and publication, as detailed below:


ARRIVE: Authors submitting research on animal studies are now required to complete an adapted ARRIVE (Animals in Research: Reporting In Vivo Experiments) checklist at submission.


CONSORT: Authors of manuscripts reporting results of clinical trials are now required to upload the CONSORT checklist at submission.


STROBE: Authors of manuscripts reporting results of human observational case-control, cohort, or cross-sectional studies are now required to upload the STROBE checklist at submission.


Author Agreement: The conflict of interest (COI) and copyright transfer (CTA) portions of the current Author Agreement can now be completed electronically as a web form, eliminating the need for authors to print, scan and upload a PDF form upon submission.


• COI information will be collected during submission via an online questionnaire on ScholarOne.


• The CTA will be completed at manuscript acceptance: If a manuscript is accepted for publication, the corresponding author will receive an e-mail prompt to log in to Author Services. Author Services is a Wiley web application that provides production tracking, as well as other resources for authors. From this site, corresponding authors can complete the CTA on behalf of all authors on the paper.

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