Molecular Nutrition & Food Research

Cover image for Vol. 60 Issue 5

Edited By: Hans-Ulrich Humpf

Impact Factor: 4.603

ISI Journal Citation Reports © Ranking: 2014: 4/123 (Food Science & Technology)

Online ISSN: 1613-4133

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  1. Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet

    Nadeem O. Kaakoush, Sarah I. Martire, Mukesh Raipuria, Hazel M. Mitchell, Shaun Nielsen, R. Fred Westbrook and Margaret J. Morris

    Version of Record online: 27 MAY 2016 | DOI: 10.1002/mnfr.201500815

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    The gut bacteria of rats either continuously fed standard chow or palatable cafeteria diet are compared to a third group cycled between these diets (4/3 days each wk) over 16 wks. Body weight and metabolic parameters of cycled rats were intermediate between those of the other diet groups. Gut bacteria of cycled rats were nearly indistinguishable from rats under constant cafeteria diet, and both groups were different to the chow group. Thus, any exposure to junk food affects gut bacteria.

  2. Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits

    Francisco J. Ortega, Zaida Agüera, Mònica Sabater, José M Moreno-Navarrete, Isabel Alonso-Ledesma, Gemma Xifra, Patricia Botas, Elías Delgado, Susana Jimenez-Murcia, José C. Fernández-García, Francisco J Tinahones, Rosa M. Baños, Cristina Botella, Rafael de la Torre, Gema Frühbeck, Amaia Rodrigüez, Xavier Estivill, Felipe Casanueva, Wifredo Ricart, Fernando Fernández-Aranda and José M. Fernández-Real

    Version of Record online: 27 MAY 2016 | DOI: 10.1002/mnfr.201500804

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    Here, we demonstrate that genetic variations that underlie functionality of the TAS2R38, a receptor that regulates the ability to identify bitter-tasting compounds, may impact on phenotypic and clinical outputs affecting extreme weight conditions (i.e., obesity and anorexia nervosa), being also associated with proteins partaking in innate immunity (i.e., surfactant protein D (SPD) and mannanbinding lectin (MBL)).

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    Prenatal caprine milk oligosaccharide consumption affects the development of mice offspring

    Caroline Thum, Warren C. McNabb, Wayne Young, Adrian L. Cookson and Nicole C. Roy

    Version of Record online: 27 MAY 2016 | DOI: 10.1002/mnfr.201600118

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    The maternal microbiota is the main source of bacteria colonizing the infant gastrointestinal tract and can be modified by dietary prebiotics. Caprine milk oligosaccharides (CMO) are complex sugars with potential prebiotic effects. We demonstrated that consumption of CMO by the dams during gestation and lactation improved the development of the pups, and the relative abundance of bifidobacteria and butyric acid in the colon, at weaning. Pups, from dams-fed CMO diet, consuming control diet for 30 days post weaning had increased body fat and leptin concentration.

  4. Inhibition of PDGF-induced migration and TNF-α-induced ICAM-1 expression by maltotetraose from bamboo stem extract (BSE) in mouse vascular smooth muscle cells

    Soon Young Shin, You Jung Jung, Yeonjoong Yong, Hi Jae Cho, Yoongho Lim and Young Han Lee

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/mnfr.201500601

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    Bambusae caulis in liquamen (BCL) is a nutritious liquid extracted from heat-treated stems of bamboo species. The effect of BCL on the migration of VSMCs has not been well characterized. This study shows that BSE inhibited PDGF-induced migration of vascular smooth muscle cells (VSMC), suppress TNF-α-induced ICAM-1 expression by inhibiting NF-κB activity in VSMC, and reduce adhesion between VSMC and monocytes. It is found that maltotetraose is a major functional constituent of BSE responsible for inhibition of migration and ICAM-1 expression in VSMC.

  5. (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss

    Zachary T. Bitzer, Ryan J. Elias, Matam Vijay-Kumar and Joshua D. Lambert

    Accepted manuscript online: 24 MAY 2016 04:15AM EST | DOI: 10.1002/mnfr.201501042