Advanced Biosystems

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Advanced Biosystems extends the prestigious Advanced journal family into the Life Sciences. This new journal publishes the best research into technologies that enhance and harness biological systems, such as cell and tissue engineering, synthetic biology and biomimetics, therapeutics and diagnostics, biomaterials and biotechnology, and the interaction of the biological world with physical sciences and engineering.

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Recently Published Articles

  1. Constructing Synthetic Ecosystems with Biopolymer Fluitrodes

    Phu L. H. Pham, Seyed A. Rooholghodos, John S. Choy and Xiaolong Luo

    Version of Record online: 12 FEB 2018 | DOI: 10.1002/adbi.201700180

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    Freestanding, robust, and semipermeable chitosan membranes in microfluidics are exploited as “fluitrodes” that, similar to electrodes transmitting electrons, transmit ions and small molecules with spatiotemporal programmability. The individually addressable fluitrodes allow for assembling patterned cell populations that mimic natural ecosystems, delivering separate nutrients and stimuli, collecting effluents, and releasing cells separately for downstream molecular and biochemical analyses.

  2. Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery

    Miranda M. So, Neel A. Mansukhani, Erica B. Peters, Mazen S. Albaghdadi, Zheng Wang, Charles M. Rubert Pérez, Melina R. Kibbe and Samuel I. Stupp

    Version of Record online: 12 FEB 2018 | DOI: 10.1002/adbi.201700123

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    Self-assembled peptide amphiphile nanofibers incorporating an apolipoprotein A1-mimetic peptide are designed as vehicles in a targeted drug-delivery platform for atherosclerosis. These nanofibers encapsulate hydrophobic liver X receptor (LXR) agonist molecules and effectively deliver them to cholesterol-laden mouse macrophages to increase cholesterol efflux. Fluorescence microscopy reveals that these nanofibers successfully localized to plaque sites in atherosclerotic mice.

  3. In Situ Time-Dependent and Progressive Oxidation of Reduced State Functionalities at the Nanoscale of Carbon Nanoparticles for Polarity-Driven Multiscale Near-Infrared Imaging

    Indrajit Srivastava, Santosh K. Misra, Indu Tripathi, Aaron Schwartz-Duval and Dipanjan Pan

    Version of Record online: 7 FEB 2018 | DOI: 10.1002/adbi.201800009

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    Carbon dots with surface-abundant oxidizeable functionalities undergo sequential aerial oxidation leading to polarity-driven wavelength tuning of their photoluminescence. It consequently boosts their quantum yields and improves deep tissue ex vivo and in vivo fluorescence bioimaging abilities.

  4. Bioreactors Based on Enzymes Encapsulated in Photoresponsive Transformable Nanotubes and Nanocoils End-Capped with Magnetic Nanoparticles

    Naohiro Kameta, Yuichi Manaka, Haruhisa Akiyama and Toshimi Shimizu

    Version of Record online: 1 FEB 2018 | DOI: 10.1002/adbi.201700214

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    Encapsulation of enzymes in supramolecular nanotubes consisting of monolayer membranes of an asymmetric bolaamphiphile containing an azobenzene unit and continuous end capping with magnetic nanoparticles enables the construction of bioreactors. The bioreactors allow control of enzymatic reactions by light irradiation and exhibit excellent kinetic parameters, reusability and recyclability, stabilization of encapsulated enzymes, and size selectivity for substrates.

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    From Compartmentalization of Bacteria within Inorganic Macrocellular Beads to the Assembly of Microbial Consortia

    Armand Roucher, Mickaël Morvan, Deniz Pekin, Martin Depardieu, Jean-Luc Blin, Véronique Schmitt, Manfred Konrad, Jean-Christophe Baret and Rénal Backov

    Version of Record online: 22 JAN 2018 | DOI: 10.1002/adbi.201700233

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    Bacteria in semipermeable inorganic foams are entrapped and grown to construct microbial consortia for the integration of multi-step chemical transformations. These foams, produced as millimetric beads, function as efficient living biocatalysts and can be assembled to perform preprogrammed sequences of reactions.