Advanced Biosystems

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Advanced Biosystems extends the prestigious Advanced journal family into the Life Sciences. This new journal publishes the best research into technologies that enhance and harness biological systems, such as cell and tissue engineering, synthetic biology and biomimetics, therapeutics and diagnostics, biomaterials and biotechnology, and the interaction of the biological world with physical sciences and engineering.

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Recently Published Articles

  1. Incorporation of Silicon Carbide and Diamond-Like Carbon as Adhesion Promoters Improves In Vitro and In Vivo Stability of Thin-Film Glassy Carbon Electrocorticography Arrays

    Maria Vomero, Elisa Castagnola, Juan S. Ordonez, Stefano Carli, Elena Zucchini, Emma Maggiolini, Calogero Gueli, Noah Goshi, Francesca Ciarpella, Claudia Cea, Luciano Fadiga, Davide Ricci, Sam Kassegne and Thomas Stieglitz

    Version of Record online: 17 NOV 2017 | DOI: 10.1002/adbi.201700081

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    The incorporation of silicon carbide and diamond-like carbon as adhesion promoters between glassy carbon (GC) electrodes and polyimide and between GC and platinum traces greatly improves in vitro and in vivo stability of GC electrocorticography (ECoG) arrays. The devices undergo chemically induced oxidative stress and electrical stimulation without delaminating and failing. After chronic implants, no sign of severe immune reaction is shown.

  2. Generation of Multifunctional Magnetic Nanoparticles with Amplified Catalytic Activities by Genetic Expression of Enzyme Arrays on Bacterial Magnetosomes

    Frank Mickoleit and Dirk Schüler

    Version of Record online: 17 NOV 2017 | DOI: 10.1002/adbi.201700109

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    Magnetosomes biomineralized by magnetotactic bacteria represent magnetic nanoparticles with unique physical and chemical properties. Here, a new in vivo strategy is investigated for magnetosome display of foreign polypeptides with maximized protein-to-particle ratios. Multicopy expression of arrayed foreign proteins generates biohybrid nanoparticles with several genetically encoded functionalities (i.e., magnetism, fluorescence, and high catalytic activity).

  3. Use of Tethered Hydrogel Microcoatings for Mesenchymal Stem Cell Equilibrium, Differentiation, and Self-Organization into Microtissues

    David W. Green, Gregory S. Watson, Jolanta A. Watson, Jong-Min Lee and Han-Sung Jung

    Version of Record online: 16 NOV 2017 | DOI: 10.1002/adbi.201700116

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    Stem cell therapy and stem cell-based tissue engineering can be improved by harnessing the new design and qualities of biomaterial systems. One strategy involves thin and ultrathin coating of single cells and a small cluster of cells. Here, the invention and development of a new way of attaching a hydrogel coating incorporating factors that define lineage fates and form microtissues are shown.

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    “Engineering and Life Herrenhausen Symposium” Special Issue

    Robert Lovrincic and Gerardo Hernandez-Sosa

    Version of Record online: 14 NOV 2017 | DOI: 10.1002/adbi.201700192

  5. Cell-Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis

    Murugesan Raju, Puttur Santhoshkumar and K. Krishna Sharma

    Version of Record online: 13 NOV 2017 | DOI: 10.1002/adbi.201700095

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    A peptide chaperone encapsulating the chaperone site of αA-crystallin is developed to penetrate cells and control β-Amyloid fibril formation and toxicity. In this study, the effects of the peptide on unfolding proteins and cells subjected to oxidative stress are investigated. In the presence of the peptide, suppression of unfolding protein aggregation and prevention of hydrogen peroxide-induced cellular apoptosis are observed.