Advanced Biosystems

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Advanced Biosystems extends the prestigious Advanced journal family into the Life Sciences. This new journal publishes the best research into technologies that enhance and harness biological systems, such as cell and tissue engineering, synthetic biology and biomimetics, therapeutics and diagnostics, biomaterials and biotechnology, and the interaction of the biological world with physical sciences and engineering.

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Recently Published Articles

  1. Sulfated Alginate as a Mimic of Sulfated Glycosaminoglycans: Binding of Growth Factors and Effect on Stem Cell Behavior

    Rami Mhanna, Jana Becher, Matthias Schnabelrauch, Rui L. Reis and Iva Pashkuleva

    Version of Record online: 16 JUN 2017 | DOI: 10.1002/adbi.201700043

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    Increased sulfation of biomaterials such as alginate increases binding of growth factors, mimicking the effect of natural sulfated glycosaminoglycans. Incorporating these sulfated materials in engineered layer-by-layer structures enables precise control of growth factor adsorption and subsequent stem cell fate. Alginate sulfate-based films and scaffolds can be further used for mechanistic basic science and applied tissue engineering investigations.

  2. Nanoscale Mapping of Multiple Lectins on Cell Surfaces by Single-Molecule Force Spectroscopy

    Stéphane Cuenot, Audrey Bouvrée and Jean-Philippe Bouchara

    Version of Record online: 16 JUN 2017 | DOI: 10.1002/adbi.201700050

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    Several nanoscale recognition maps, corresponding each to a unique specific receptor–ligand interaction, are performed by single-molecule force spectroscopy with different carbohydrate-functionalized atomic force microscopy tips on the same cell location. By superimposition, a nanoscale reconstructed mapping shows the spatially resolved localization, identification, and quantification of multiple lectin sites directly on the pathogen surface.

  3. Membrane Protein Insertion into and Compatibility with Biomimetic Membranes

    Tingwei Ren, Mustafa Erbakan, Yuexiao Shen, Eduardo Barbieri, Patrick Saboe, Hasin Feroz, Hengjing Yan, Samantha McCuskey, Joseph F. Hall, A. Benjamin Schantz, Guillermo C. Bazan, Peter J. Butler, Mariusz Grzelakowski and Manish Kumar

    Version of Record online: 16 JUN 2017 | DOI: 10.1002/adbi.201700053

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    Chemical and physical hydrophobicity mismatch are the key factors influencing membrane protein compatibility with biomimetic membranes. Chemical hydrophobic mismatch describes the hydrophobic character difference between protein outer surfaces and membrane hydrophobic cores. It is measured using a distyrylbenzene chromophore based assay presented in this article. Physical hydrophobicity mismatch is the thickness difference between protein hydrophobic length and bilayer hydrophobic core length.

  4. Thoughts on Scaffolds

    Suwan N. Jayasinghe

    Version of Record online: 14 JUN 2017 | DOI: 10.1002/adbi.201700067

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    Scaffolds are pivotal in the development of synthetic tissues for a wide range of applications in the biomedical and clinical sciences. Recent developments in the field of bioscaffolds are reviewed and discussed.

  5. Characterization of Covalently Bound Anti-Human Immunoglobulins on Self-Assembled Monolayer Modified Gold Electrodes

    Brigitte Holzer, Kyriaki Manoli, Nicoletta Ditaranto, Eleonora Macchia, Amber Tiwari, Cinzia Di Franco, Gaetano Scamarcio, Gerardo Palazzo and Luisa Torsi

    Version of Record online: 5 JUN 2017 | DOI: 10.1002/adbi.201700055

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    The immobilization of anti-immunoglobulin G and M on gold electrodes via self-assembled monolayers is studied as a model system for further immunoassays development. The biolayer is characterized by means of X-ray photoelectron spectroscopy, atomic force microscopy, a dedicated thin-film transistor-based platform, and electrochemical surface plasmon resonance.