Advanced Biosystems

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Advanced Biosystems extends the prestigious Advanced journal family into the Life Sciences. This new journal publishes the best research into technologies that enhance and harness biological systems, such as cell and tissue engineering, synthetic biology and biomimetics, therapeutics and diagnostics, biomaterials and biotechnology, and the interaction of the biological world with physical sciences and engineering.

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Recently Published Articles

  1. Engineering a Cell Home for Stem Cell Homing and Accommodation

    Rui-Xin Wu, Yuan Yin, Xiao-Tao He, Xuan Li and Fa-Ming Chen

    Version of Record online: 22 MAR 2017 | DOI: 10.1002/adbi.201700004

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    By orchestrating bidirectional communication with surrounding components, a well-engineered material device as a cell home ensures sufficient stem cell homing following in vivo transplantation and enables the recruited cells to respond and assimilate within its matrix to promote the formation of new tissue at the site of implantation.

  2. TopoWellPlate: A Well-Plate-Based Screening Platform to Study Cell–Surface Topography Interactions

    Nick R. M. Beijer, Aliaksei S. Vasilevich, Bayram Pilavci, Roman K. Truckenmüller, Yiping Zhao, Shantanu Singh, Bernke J. Papenburg and Jan de Boer

    Version of Record online: 21 MAR 2017 | DOI: 10.1002/adbi.201700002

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    The TopoWellPlateis a novel system to study cell–surface topography interaction in high-throughput. From a library of topographies, 87 uniquely defined bioactive surface topographies are identified, which induce a wide variety of cellular morphologies. Topographically enhanced polystyrene films are fabricated in order to create cell culture ready 96-well plates to study biomaterial-induced mechanotransduction.

  3. Co-Delivery of Disease Associated Peptide and Rapamycin via Acetalated Dextran Microparticles for Treatment of Multiple Sclerosis

    Naihan Chen, Kevin J. Peine, Michael A. Collier, Shalini Gautam, Kyle A. Jablonski, Mireia Guerau-de-Arellano, Kristy M. Ainslie and Eric M. Bachelder

    Version of Record online: 10 MAR 2017 | DOI: 10.1002/adbi.201700022

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    Current therapies for multiple sclerosis (MS) ameliorate the symptoms through broad immune suppression and are associated with severe side effects. Acetalated dextran (Ace-DEX) microparticles (MPs) are proposed as a potential MS treatment through the induction of antigen-specific tolerance, which inhibits disease progression without sacrificing immune competence. Ace-DEX MPs encapsulating rapamycin and the disease-associated peptide significantly slow disease progression when tested in a mouse model for MS.

  4. Devitalized Stem Cell Microsheets for Sustainable Release of Osteogenic and Vasculogenic Growth Factors and Regulation of Anti-Inflammatory Immune Response

    Seyedsina Moeinzadeh, Seyed Ramin Pajoum Shariati, Safaa Kader, Juan M. Melero-Martin and Esmaiel Jabbari

    Version of Record online: 7 MAR 2017 | DOI: 10.1002/adbi.201600011

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    Devitalized cells are attractive as a source for sustained release of a mixture of cytokines. Human mesenchymal stem cells (hMSCs) and endothelial colony forming cells (ECFCs) are seeded on calcium phosphate-nucleated microsheets, cultured for differentiation to a specified lineage, and devitalized by lyophilization. Undifferentiated hMSC and differentiated ECFC have highest release of morphogenetic protein-2 and vascular endothelial growth factor, respectively.

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    Advanced Goes Bio: Welcome to Advanced Biosystems

    Kerstin Brachhold, Uta Goebel, Emily Hu and Lorna Stimson

    Version of Record online: 22 FEB 2017 | DOI: 10.1002/adbi.201700016