American Journal of Hematology

Cover image for Vol. 91 Issue 6

Edited By: Carlo Brugnara

Impact Factor: 3.798

ISI Journal Citation Reports © Ranking: 2014: 17/68 (Hematology)

Online ISSN: 1096-8652

Author Guidelines

NIH Public Access Mandate
For those interested in the Wiley-Blackwell policy on the NIH Public Access Mandate, please visit our policy statement

For additional tools visit Author Resources - an enhanced suite of online tools for Wiley Online Library journal authors, featuring Article Tracking, E-mail Publication Alerts and Customized Research Tools.

Author Guidelines

Wiley's Journal Styles

Submission and Contact Information

American Journal of Hematology welcomes submitted manuscripts online at:

When uploading the manuscript files into the journal's online program, each table and each figure should be in a separate file. Tables and figures should not be in the same file as the manuscript text. Tables are to be numbered consecutively with Roman numerals, with figures in Arabic. See also Figures (below) for specifications.

The title page should contain the complete title of the manuscript, the names, degrees, and affiliations of all authors, as well as the name, address, phone, fax and email of the person to whom all correspondence should be addressed. The title page should also include the abstract word count, text word count, the number of tables and figures, a short running title, and three to six keywords to index the content.

When submitting the manuscript online, provide the names, affiliations, and email addresses of three preferred reviewers at institutions other than those of the authors.

The total number of words in the text, as well as the number of figures and tables should be listed at the bottom of the title page.

Authors are encouraged to check for an existing account. If you are submitting for the first time, and you do not have an existing account, then you must create a new account. Once you have logged in, you will be presented with the Main Menu and a link to your Author Center. Submit your manuscript from the Author Center. At the end of a successful submission, a confirmation screen with a manuscript number will appear, and you will receive an e-mail confirming that the manuscript has been received by the journal. If this does not happen, please check your submission and/or contact our Help Desk at .

Editorial Office:

Hillary Bixby
John Wiley & Sons
350 Main Street
Malden, MA 02478

Editor in Chief:
Carlo Brugnara, MD
Department of Laboratory Medicine,
Children’s Hospital Boston
300 Longwood Avenue, BA 760
Boston, MA 02115, USA
Phone: 617.355.6610
Fax: 617.730.0383

Submission Requirements

All manuscripts submitted to the American Journal of Hematology must be submitted solely to this journal. Submissions may not have been published in any part or form in another publication of any type, professional or lay, or become the property of another publisher. Any material reproduced or adapted from any other published or unpublished source must be duly acknowledged. It is the author's responsibility to obtain permission to reproduce copyrighted material. Upon submission of a manuscript for publication, the author will be requested to sign an agreement transferring copyright to the publisher, who reserves copyright. Material published in this journal may not be reproduced or published elsewhere without the written permission of the publisher and the author. All statements in, or omissions from, published manuscripts are the responsibility of the author who will assist the editor and publisher by reviewing proofs. No page charges will be levied against authors or their institutions for publication in this journal.

All authors should have contributed in a significant manner and be in agreement with all content in a manuscript. The corresponding author will take responsibility for upholding this requirement.

Wiley suggests that authors from non-English speaking countries have their manuscript reviewed and corrected by English Language Services before submission. Please see the following link from Wiley-Blackwell as we have adopted their policy:


Manuscripts are usually assigned to one of the Associate Editors. Every submitted manuscript will undergo a rapid in-house review to determine if it is suitable for the journal and if it has priority ranking in relationship to all other manuscript being considered for publication that would justify a review by external experts. Manuscripts will be rejected without external review if they are deemed not suitable for the journal or if they have low priority ranking. Manuscripts are usually sent out for review to at least two external, expert reviewers. AJH will try to follow authors’ suggestions for possible inclusion or exclusion of specific experts in the field. Authors will receive e-mail notification concerning the final editorial decision, with comments from reviewers and editors when applicable.

As stated in the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication” ( ; Updated February 2006): “ If the manuscript has been submitted previously to another journal, it is helpful to include the previous editor’s and reviewers’ comments with the submitted manuscript, along with the authors’ responses to those comments. Editors encourage authors to submit these previous communications and doing so may expedite the review process .” For manuscripts previously submitted to other journals with impact factor more than 8 , if authors include previous editor’s and reviewers’ comments along with their responses, the American Journal of Hematology will guarantee a rapid (within a week) in-house assessment, with three possible outcomes:
a) Acceptance or acceptance with minor changes (no additional external reviews needed);
b) Rejection;
c) Additional external review needed; in this case the authors will have the possibility of accepting the additional external review or withdrawing the manuscript.
d) When submitting a paper for Rapid Review, upload a Word document containing the previous review comments and your responses as “Supplementary Material for Review." After submitting the manuscript, please e-mail the editorial office at along with your assigned manuscript number (AJH-XX-XXXX) to alert the editorial office to your submission.

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions

For authors choosing OnlineOpen

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

For RCUK and Wellcome Trust authors click on the link below to preview the terms and conditions of this license:

Creative Commons Attribution License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

DISCLOSURE STATEMENT. All authors must disclose any affiliations that they consider to be relevant and important with any organization that to any author's knowledge has a direct interest, particularly a financial interest, in the subject matter discussed. Such affiliations include, but are not limited to, employment by an industrial entity, ownership of stock, membership on a standing advisory council or committee, a seat on the board of directors, or being publicly associated with a company or its products. Other areas of real or perceived conflict of interest would include receiving honoraria or consulting fees or receiving grants or funds from corporations or individuals representing such corporations. This requirement will apply to every sort of article submitted to the Journal , including original research, reviews, editorials, letters to the editor, and any others, and should be disclosed at the time of submission. The simplest remedy for conflict of interest is disclosure. In the Journal , disclosure will henceforth be achieved by the inclusion of a short footnote with each published article. This information will be held in confidence while the paper is under review. It will not be shared with peer reviewers, and it will not influence the editorial decision to accept or reject the manuscript. When an article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be presented.

RESEARCH ARTICLES. Articles should represent original and in-depth studies involving all aspects of clinical or laboratory investigations. While there is no length restriction for articles, authors are encouraged to limit the text to a maximum length of 5,000 words and references to no more than 100. The number of illustrations and tables should be appropriate for the data presented, but should not repeat information in the text.

The title page should contain the complete title of the manuscript, the names, degrees, and affiliations of all authors as well as the name, address, phone, fax and email of the person to whom all correspondence should be addressed. While the number of authors should usually not exceed six, exceptions will be granted with adequate justification. The title page should also include the abstract word count, text word count, the number of tables and figures, a short running title, and three to six keywords to index the content.

Abstract. This should be a factual condensation of the entire work, including a statement of its purpose, a clear description of the findings, including numbers, and finally a concise presentation of the conclusions. The abstract may not exceed 250 words.

Text. The text should follow the following format: Introduction, Methods, Results, and Discussion (please note that this has been recently changed so that Methods is at the top of the paper, placed in between Introduction and Results). Place Acknowledgments as the last element of the text, before references. Use subheadings and paragraph titles when possible. Authors whose first language is not English should arrange for their manuscripts to be written in idiomatic English and reviewed prior to submission by an editor facile in medical English. This will avoid disappointing delays before a paper can be sent out for review. Please see the "Submission requirements" section above for guidelines relating to language.

Patients should be referred to only by subject numbers and not with names, initials, or other potentially identifying characters. Manuscripts reporting the results of experimental investigations on human subjects must include a statement to the effect that the procedures received official institutional approval.

Use non-capitalized generic names (e.g., cyclophosphamide) for all drugs and pharmaceutical preparations. Trade names (capitalized) for appliances, etc., may be used in the Methods section, and the manufacturers should be identified by name and address.

Any tables submitted with the text should be sent/uploaded as separate Word files.

References. Authors are responsible for the accuracy of references. In the text, cite references consecutively as numerals in brackets; all references must be cited in either text or tables. Unpublished data, and personal communications should not be listed as references. Arrange the references in numerical order, and include the names of all authors up to four in number. If the authors number more than four, list the first three followed by "et al." The complete title of the article cited and inclusive page numbers follow. Abbreviate journal names according to Index Medicus. In the following examples, notice the punctuation and order of information: do not use all capitals, do not underline titles.

Journal articles:

1. Kaplan R, DeLa Cadena RA. Mechanism of the coagulopathy associated with acute promyelocytic Leukemia. Am J Hematol 1998;59:234-237.


2. Bricker JT, Green DM, D'Angio GJ, editors. Cardiac toxicity after treatment for childhood cancer. New York: Wiley-Liss, Inc.; 1993. 1223 p.

Articles in Books:

3. Gerber JE. The role of genetic counseling in the management of long-term survivors of childhood cancer. In: Bricker JT, Green DM, D'Angio GJ, editors. Cardiac toxicity after treatment for childhood cancer. New York: Wiley-Liss, Inc.; 1993. p 121-150.

Wiley's Journal Styles are Now in Endnote. EndNote is a software product that we recommend to our journal authors to help simplify and streamline the research process. Using EndNote's bibliographic management tools, you can search bibliographic databases, build and organize your reference collection, and then instantly output your bibliography in any Wiley reference style. If you already use EndNote, you can download the reference style for this journal. How to Order: To learn more about EndNote, or to purchase your own copy, click here .

Technical Support: If you need assistance using EndNote, contact , or visit .

Video Summaries: A video summary can be a quick way to make the message of your research accessible to a much larger audience. Wiley and its partner Research Square offer a service of professionally produced video summaries, available to authors of articles accepted in this journal. You can learn more about it, and purchase one for your article, at . If you have any questions, please direct them to .

Manuscript: For optimal production, prepare manuscript text using Microsoft Word. Please note: This journal does not accept Microsoft WORD 2007 documents at this time. Please use WORD’s “Save As” option to save your document as an older (.doc) file type.

Figures: When preparing digital art, please submit your figures and tables as separate files and consider the following:


The minimum requirements for resolution are:

  • 1200 DPI/PPI for black and white images, such as line drawings or graphs.
  • 300 DPI/PPI for picture-only photographs
  • 600 DPI/PPI for photographs containing pictures and line elements, i.e., text labels, thin lines, arrows.

These resolutions refer to the output size of the file; if you anticipate that your images will be enlarged or reduced, resolutions should be adjusted accordingly.


For the entire submission/acceptance process, EPS or TIFF files will be required. For the editorial review process, color images may be submitted in RGB color; upon acceptance, CMYK color will be required. Delivery of production-quality files early in the review process may help facilitate smooth and rapid publication once a manuscript has been accepted.

A legend must be provided for each illustration and must define all abbreviations used therein. Legends should be placed at the end of the manuscript text file or below each figure. Please be sure to submit your figures and tables as separate files.

Authors are encouraged to submit color illustrations that highlight the text and convey essential scientific information. All color figures will be reproduced in full color in the online edition of the journal at no cost to authors. Authors are requested to pay the cost of reproducing color figures in print. For best reproduction, use bright, clear colors. Dark colors against a dark background do not reproduce well; please place your color images against a white background wherever possible. Please contact for further information.

CRITICAL REVIEWS. Reviews of important and timely subjects can be invited by the editorial board or submitted independently. In the latter case, it is usually helpful for the corresponding author to consult the Editor-in-Chief prior to submission. Reviews should focus on the critical aspects of a subject, linking established knowledge to areas that remain controversial or unanswered. Reviews should normally comprise less than 6,000 words, contain an unstructured abstract of 100 words or less, and use fewer than 150 references; illustrations and tables should be used only to provide summaries or a synthesis of ideas and/or data not included in the text.

REVIEWS OF BOOKS AND OTHER MEDIA FORMATS. Reviews of books, films, or other media formats relevant to the scientific or clinical practice of medicine, with particular importance to hematology/oncology, may be invited or submitted independently. In the latter case, please consult with the Editor-in-Chief prior to submission.

CORRESPONDENCE. Correspondence should usually be in reference to previously published manuscripts in American Journal of Hematology . However, correspondence relating to important and timely publications or topics from other sources may also be appropriate. Brief descriptions of interesting laboratory or clinical observations may also be appropriate. Correspondence to the Editor should be no more 1,000 words, no more than 6 references and one table/figure.

COMMENTARY. Commentaries are usually invited but may be submitted independently after consultation with the Editor-in-Chief. Please limit the text to 2,500 words and fewer than 10 references. Commentaries should focus on a controversial subject arising from a recently published American Journal of Hematology manuscript, but they may also focus on independent and timely topics of relevance to the journal’s readership. Illustrations and Tables are allowed only if they highlight or clarify points made in the text. Commentaries will be reviewed and may require changes or be rejected.

MEETING REPORTS AND SUPPLEMENTS. Concise summaries of meetings that have important information to convey to the readers of American Journal of Hematology are welcomed, but consultation with the Editor-in-Chief should occur before submission. Summaries should emphasize the issues discussed at the meeting along with an explanation of how they are important or controversial. Summaries should be less than 2000 words. Illustrations and tables may be included but only when they add significantly to the text content. More extensive reports with manuscripts from the speakers are also welcomed, but early consultation with the Editor-in-Chief must take place in order to determine the type and number of manuscripts to be published, the review process, and the procurement of additional funding if required.

TEST OF THE MONTH. Please consult with the Editor-in-Chief before submission. This new feature should include a discussion of a specific laboratory test/parameter that is relevant for hematologist/oncologists and for any clinicians dealing with blood disorders. It should summarize technical specifications and issues, clinical performance and pitfalls, and provide evidence of sensitivity and specificity, particularly discussing disease conditions if available. Manuscript length should be no more than 1,500 words with no more than 25 references.

SOLVING CLINICAL PROBLEMS IN BLOOD DISEASES. The format of this case presentation should be similar to that used in the Clinical problem-solving articles of the New England Journal of Medicine (see as an example: Prasad M et al. New Engl J Med 2006 355:2468-2473 ). These articles should reproduce the step-by-step process used by clinicians dealing with novel and/or unusually challenging clinical presentations of hematological diseases. Clinical information must be presented in stages (boldface type), followed by the clinical reasoning of the physician taking care of such a patient, and a final discussion of the case as it relates to disease pathophysiology, complications, treatment, and treatment outcomes. Manuscript length should be no more than 2,500 words, with no more than 25 references.

IMAGES IN HEMATOLOGY. We believe that the discipline of hematology lends itself particularly well to visual case presentations. The purpose of this section of the Journal , therefore, is to present an interesting visual description of a defined hematological condition. The image may consist of a single photo or a series of photos that, when grouped together, give a visual description of the specific hematological entity. It is expected that the submitting authors(s) will supplement the visual "Image" with brief text as necessary to tell the full story. Whenever appropriate, we will publish the images in full color.

DIAGNOSTIC IMAGING IN HEMATOLOGY: a variety of techniques (X-rays, CT scans, MRI, Nuclear Medicine scans and ultrasound) are routinely utilized in the diagnosis and treatment of hematological diseases. The purpose of this section of the Journal is to provide images of techniques which provide relevant diagnostic and clinical information for physicians managing patients affected by Blood Diseases.

UPDATES IN CLINICAL TRAILS FOR HEMATOLOGICAL DISEASES. These are invited submissions, and any submissions in this category must be cleared by the editor first. If you wish to submit in this category, please contact the editorial office.

We work together with two Wiley’s open access journals, Clinical Case Reports and Cancer Medicine, to enable rapid publication of good quality manuscripts that we are unable to accept for publication in our journal. Authors may be offered the option of having their paper, along with any related peer reviews, automatically transferred for consideration by the Editor of either Clinical Case Reports or Cancer Medicine. Authors will not need to reformat or rewrite their manuscript at this stage, and publication decisions will be made a short time after the transfer takes place. Clinical Case Reports will consider case reports from every clinical discipline and may include clinical images or clinical videos. The Editor of Cancer Medicine will accept submissions that report well-conducted research in oncology which reaches the standard acceptable for publication. Clinical Case Reports and Cancer Medicine are open access journals, and article publication fees apply. For more information please go to or

??? Production Questions ???