Journal of Comparative Neurology

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Impact Factor: 3.331

ISI Journal Citation Reports © Ranking: 2015: 7/160 (Zoology); 91/256 (Neurosciences)

Online ISSN: 1096-9861

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Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues
Corrado Calì, Jumana Baghabra, Daniya J. Boges, Glendon R. Holst, Anna Kreshuk, Fred A. Hamprecht, Madhusudhanan Srinivasan, Heikki Lehväslaiho and Pierre J. Magistretti

Mapping chromatic pathways in the Drosophila visual system
Tzu-Yang Lin, Jiangnan Luo, Kazunori Shinomiya, Chun-Yuan Ting, Zhiyuan Lu, Ian A. Meinertzhagen and Chi-Hon Lee

Projections from the subparaventricular zone define four channels of output from the circadian timing system
Nina Vujovic, Joshua J. Gooley, Thomas C. Jhou and Clifford B. Saper

Prefrontal cortex afferents to the anterior temporal lobe in the Macaca fascicularismonkey
Alicia Mohedano-Moriano, Mónica Muñoz-López, Ernesto Sanz-Arigita, Palma Pró-Sistiaga, Alino Martínez-Marcos, María Ester Legidos-Garcia, Ana María Insausti, Sandra Cebada-Sánchez, María Del Mar Arroyo-Jiménez, Pilar Marcos, Emilio Artacho-Pérula and Ricardo Insausti

Cowan Award

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Marry E. Hatten

The 2015 Cowan Award was presented to Dr. Mary E. Hatten, in recognition of her outstanding contributions to developmental neuroscience.

Dr. Hatten received her PhD in biochemical sciences from Princeton University in 1975 and completed her postdoctoral training in neuroscience at Harvard Medical School. She was on the New York University School of Medicine faculty from 1978 to 1987 and then moved to the College of Physicians and Surgeons at Columbia University. She went to the Rockefeller University in 1992 where she was named the Frederick P. Rose Professor in 2000. Dr. Hatten was also the Wiersma Visiting Professor of Neuroscience at the California Institute of Technology in 2005.

Dr. Hatten has contributed major discoveries on how the complex cellular architecture of the mammalian brain is assembled during development, focusing on cell differentiation and migration. Her work has had significant impact on genetic studies on human brain disorders, as well as important applications in the context of clinical conditions resulting from developmental brain abnormalities, in particular autism spectrum disorder and childhood epilepsy. Her research on cerebellar development has also provided insights on the pathophysiology of medulloblastoma, the most prevalent metastatic brain tumor in children. She also pioneered the development of video imaging approaches that permit dynamic visualization of neurons motion along glial fibers. Her work was recognized by many awards, such as the McKnight Endowment Fund for Neuroscience Investigator Award, the Javits Neuroscience Investigator Award, and a Faculty Award for Women Scientists and Engineers from the National Science Foundation.

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

Published with OnlineOpen, this article is freely available to read now!

The Toolbox article by Cali and colleagues (J Comp Neurol 2016;524.1:23-38) represents the early stage of a “dream come true” for this morphology-attuned neuroscientist. I have always felt that if I could walk through a neuron in a “fully immersive virtual reality environment” I would gain insights that would not be possible otherwise. Our world is 3-dimensional and our visual system is designed to perceive and navigate structures in 3-dimensional space. The fact that the 3D CAVE (cave automatic virtual environment) developed by Cali et al. is also robustly quantitative, takes it to an entirely different level where one not only can appreciate the true spatial relationships of the complex ultrastructural reality, but the relative distribution and distance between synaptic elements can also be accurately measured. Such measurements and the resultant models will surely reveal patterns that are not apparent in 2-dimension or less robust reconstructions, such as the fascinating distribution of glycogen granules relative to synaptic compartments reported in this study. Each of us can imagine using such an approach to gain insights into our own favorite synaptic elements, like phospho-tau accumulations relative to dendritic arbors and spine classifications, quantitative mapping of receptor protein localization in synaptic compartments, or the distribution of normal and pathologic mitochondria in the context of other synaptic attributes. I congratulate the authors on the development of not only a powerful approach to high-resolution analysis of the nervous system, but I also would like to thank them for providing a new reality that is certain to generate a great deal of fun. 

Click here to view an amazing video and experience the 3D CAVE for yourself!

John H. Morrison, PhD

Professor, Department of Neurology, School of Medicine

University of California, Davis

Dr. Harvey Karten Elected to National Academy of Sciences

The Journal of Comparative Neurology is proud to congratulate our editorial board member, Dr. Harvey Karten, on his recent election to the National Academy of Sciences. Dr. Karten is professor emeritus at the School of Medicine at University of California, San Diego and his research has included groundbreaking insight into avian and mammalian brain microarchitecture and connectivity, providing novel concepts and a deeper understanding of evolution and development of neural systems in vertebrates. Dr. Karten is also a pioneer in the development of digitized brain atlases and of cell-based databases of brain regions, neurons and their connections across vertebrates. Dr. Karten has been an invaluable member of our editorial board and we offer our very best congratulations.


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