Journal of Comparative Neurology

Cover image for Vol. 522 Issue 10

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)


Impact Factor: 3.661

ISI Journal Citation Reports © Ranking: 2012: 3/151 (Zoology); 82/252 (Neurosciences)

Online ISSN: 1096-9861


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  1. Research Articles

    1. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex

      Margaret A. Cooper and Anthony J. Koleske

      Accepted manuscript online: 19 APR 2014 12:04AM EST | DOI: 10.1002/cne.23615

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      ErbB4 is a receptor tyrosine kinase known to be associated with schizophrenia in genetic linkage studies. Using a conditional ErbB4 knockout mouse, the authors show that dendritic spine density is reduced in the prefrontal cortex and that ErbB4 can regulate dendritic spine development in excitatory neurons.

    2. The neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections

      Eran Finkel, Alex Etlin, Meir Cherniak, Yoav Mor, Aharon Lev-Tov and Lili Anglister

      Accepted manuscript online: 18 APR 2014 01:55AM EST | DOI: 10.1002/cne.23613

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      The authors describe a muscarinic receptor-dependent modulation of the locomotor output produced by stimulating sacrocaudal afferents in rodent spinal cord, following exposure of sacral segments to the cholinesterase blocker edrophonium (EDRO). Acetylcholinesterase, choline-acetyltransferase, M2-muscarinic receptors, and cholinergic synapses identified on sacral relay neurons projecting to the lumbar segments via the ventral funiculi (VF-neurons) are suggested to mediate this cholinergic modulation. *= VF-neurons with cholinergic components.

    3. Cortical innervation of the hypoglossal nucleus in the non-human primate (Macaca mulatta)

      Robert J. Morecraft, Kimberly S. Stilwell-Morecraft, Kathryn M. Solon-Cline, Jizhi Ge and Warren G. Darling

      Accepted manuscript online: 18 APR 2014 01:15AM EST | DOI: 10.1002/cne.23614

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      We examined the cortical projection to the hypoglossal nucleus in the rhesus monkey using high-resolution anterograde tract tracers. We found 11 cortical regions innervate the nucleus. Dense terminal projections arose from M1, more moderate terminal projections from LPMCv and M2 and considerably less terminals originated from the other cortical regions.

    4. A general principle governs vision dependent dendritic patterning of retinal ganglion cells

      Hong-Ping Xu, Jin-Hao Sun and Ning Tian

      Accepted manuscript online: 16 APR 2014 05:14AM EST | DOI: 10.1002/cne.23609

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      A general structural design principle governs the vision dependent dendritic patterning of retinal ganglion cells regardless of their cell types, retinal locations and developmental stages.

    5. Photoreceptor topography and spectral sensitivity in the common brushtail possum (Trichosurus vulpecula)

      Lisa M. Vlahos, Ben Knott, Krisztina Valter and Jan M. Hemmi

      Accepted manuscript online: 16 APR 2014 04:37AM EST | DOI: 10.1002/cne.23610

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      Immunohistochemistry in Trichosurus vulpecula reveals three cone subpopulations recognized within two spectrally distinct cone classes, each with differing regional characteristics. The topographical distribution of cones provides useful information about the importance of specific visual fields in their environment, and offers new insights into the evolution of marsupial colour vision.

  2. Review

    1. Self-organisation of neural tissue architectures from pluripotent stem cells

      Michael Karus, Sandra Blaess and Oliver Brüstle

      Accepted manuscript online: 16 APR 2014 04:34AM EST | DOI: 10.1002/cne.23608

    2. Harnessing neurogenesis for the possible treatment of Parkinson's disease

      Omri Lamm, Javier Ganz, Eldad Melamed and Daniel Offen

      Accepted manuscript online: 10 APR 2014 04:50AM EST | DOI: 10.1002/cne.23607

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      In this article we review the neurogenic process, focusing on the dopaminergic system in the context of Parkinson's disease. We here described several attempts to induce the generation of new dopaminergic cells within the brain. We speculate the implication on future therapies in Parkinson's disease.

  3. Research Articles

    1. Spatio-temporal expression analysis of the growth factor receptor SorCS3

      Sandra Oetjen, Claudia Mahlke, Irm Hermans-Borgmeyer and Guido Hermey

      Accepted manuscript online: 9 APR 2014 03:39AM EST | DOI: 10.1002/cne.23606

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      Using in situ hybridizations we provide a comprehensive description of the dynamic developmental expression pattern of SorCS3 in comparison to SorCS1 and SorCS2. On the cellular level, we demonstrate that the SorCS3 cytoplasmic domain targets the receptor to vesicles in the soma, dendrites, and postsynaptic compartments and that it conveys internalization through canonical endocytic motifs.

    2. Organization of the spinal trigeminal nucleus in Star-Nosed Moles

      Eva K. Sawyer, Duncan B. Leitch and Kenneth C. Catania

      Accepted manuscript online: 9 APR 2014 03:31AM EST | DOI: 10.1002/cne.23605

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      Using multi-unit electrophysiological mapping and histology the authors show that the somatosensory star is represented in a visibly segmented map in the spinal trigeminal nucleus of the star-nosed mole (Condylura cristata), analogous to barrelettes in mice and rats. By measuring the volume of tissue devoted to of the each nasal rays and comparing this to known star representations in other somatosensory relays, we show that the rays are represented in unique proportions in the spinal trigeminal subnucleus interpolaris. This suggests anatomically-defined, area-specific specialization to different facets of touch.

    3. Induction of early neural precursors and derivation of tripotent neural stem cells from human pluripotent stem cells under xeno-free conditions

      H.X Nguyen, U Nekanti, D.L Haus, G Funes, D Moreno, N Kamei, B.J Cummings and A.J Anderson

      Accepted manuscript online: 9 APR 2014 03:31AM EST | DOI: 10.1002/cne.23604

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      Xeno-free (XF) transition and neuralization of hESC and hiPSC had reproducibly generated neuralized sphere and adherent hNSC with tripotent differentiation potential and normal karyotype. This was accomplished through a one-step XF transition protocol for hESC/hiPSC and the neural derivation of neuralized spheres and adherent hNSC under XF substrate and media conditions.

    4. GABAergic and Glutamatergic Efferents of the Mouse Ventral Tegmental Area

      Seth R Taylor, Sylvia Badurek, Ralph J DiLeone, Raad Nashmi, Liliana Minichiello and Marina R Picciotto

      Accepted manuscript online: 9 APR 2014 03:21AM EST | DOI: 10.1002/cne.23603

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      Cell-specific anterograde tracing and retrograde tracing revealed that GABAergic and glutamatergic neurons from the ventral tegmental area project to limbic structures throughout the forebrain and brainstem. The GABAergic projections were concentrated in areas that received minor dopaminergic innervation, suggesting functions for ventral midbrain GABA neurons independent of local dopamine neuron inhibition.

    5. Catecholaminergic connectivity to the inner ear, central auditory and vocal motor circuitry in the plainfin midshipman fish, Porichthys notatus

      Paul M. Forlano, Spencer D. Kim, Zuzanna M. Krzyminska and Joseph A. Sisneros

      Accepted manuscript online: 8 APR 2014 11:51AM EST | DOI: 10.1002/cne.23596

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      The authors demonstrate tyrosine hydroxylase terminals (red) onto sensory hair cells (HC, green) in the main endorgan of hearing of a non-mammalian vertebrate and confirm the origin of these efferents to be large dopaminergic diencephalic neurons in the periventricular posterior tuberculum using neural tract tracing combined with immunofluorescence.

    6. Central Pupillary Light Reflex Circuits in the Cat: I. The Olivary Pretectal Nucleus

      Wensi Sun and Paul J. May

      Accepted manuscript online: 5 APR 2014 04:08AM EST | DOI: 10.1002/cne.23602

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      Graphical Abstract

      The central pathways subserving the feline pupillary light reflex were examined by defining retinal input to the olivary pretectal nucleus, its midbrain projections, and the premotor neurons within it. Fusiform olivary neurons receive monosynaptic input from the retina and project to the anterior portion of the preganglionic motoneuron population.

    7. Central Pupillary Light Reflex Circuits in the Cat: II. Morphology, Ultrastructure and Inputs of Preganglionic Motoneurons

      Wensi Sun and Paul J. May

      Accepted manuscript online: 5 APR 2014 03:57AM EST | DOI: 10.1002/cne.23601

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      Graphical Abstract

      The preganglionic parasympathetic motoneurons controlling the pupil in the cat differ in distribution, morphology and ultrastructure from those that control the lens. Fusiform pupillary motoneurons lie rostral to the oculomotor nucleus. Multipolar lens motoneurons lie dorsal and ventral to it. The former receive monosynaptic input from the olivary pretectal nucleus.

    8. Developmental remodeling of corticocortical feedback circuits in ferret visual cortex

      Reem Khalil and Jonathan B. Levitt

      Accepted manuscript online: 25 MAR 2014 01:15AM EST | DOI: 10.1002/cne.23591

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      Using retrograde tracing techniques, the authors defined the postnatal refinement of cortical feedback inputs to primary visual cortex (V1). While the basic pattern of cortical feedback to V1 is present before eye opening, there is major reorganization after eye opening that occurs synchronously in multiple visual areas, suggesting a crucial role for visual experience in this remodeling process.

    9. Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at chronic stage

      Svitlana Garbuzova-Davis, Edward Haller, Stephanie N. Williams, Eithan D. Haim, Naoki Tajiri, Diana G. Hernandez-Ontiveros, Aric Frisina-Deyo, Sean M. Boffeli, Paul R. Sanberg and Cesario V. Borlongan

      Accepted manuscript online: 8 MAR 2014 06:02AM EST | DOI: 10.1002/cne.23582

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      Results from our study show not only significant BBB alterations in the ipsilateral hemisphere, but also demonstrate, for the first time, changes in the contralateral hemisphere 30 days after an ischemic insult using a transient MCAO rat model. These widespread microvascular alterations in ipsi- and contralateral hemispheres shown to be closely associated with BBB breakdown in chronic ischemia represent novel findings.

    10. You have full text access to this OnlineOpen article
      Feedforward and feedback connections and their relation to the CytOx modules of V2 in Cebus monkeys

      Sheila Nascimento-Silva, Carmen Pinõn, Juliana G.M. Soares and Ricardo Gattass

      Accepted manuscript online: 1 MAR 2014 11:31PM EST | DOI: 10.1002/cne.23571

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      Diagram of V4-projecting cells (orange triangles) and terminals (blue dots) located in thin (yellow) CytOx-rich stripes and interstripes avoiding the CytOx-rich thick (green) stripes in V2. The origin of the feedforward connections of V2 were located in the supragranular layers and sparsely located in the infragranular layers while the feedback projections to V2 (terminals) were located mostly in infragranular layers. The feedforward projections were located in CytOx-rich thin stripes and CytOx-poor interstripes while the feedback projections were more abundant in the thin stripes than in the interstripes.

    11. Slow-pressor angiotensin II hypertension and concomitant dendritic NMDA receptor trafficking in estrogen receptor beta-containing neurons of the mouse hypothalamic paraventricular nucleus are sex and age dependent

      Jose Marques-Lopes, Tracey Van Kempen, Elizabeth M. Waters, Virginia M. Pickel, Costantino Iadecola and Teresa A. Milner

      Accepted manuscript online: 23 FEB 2014 04:13AM EST | DOI: 10.1002/cne.23569

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      Following ‘slow-pressor” Angiotensin II infusion, ultrastructural analysis of the mouse hypothalamic paraventricular nucleus shows that NR1-silver-intensified immunogold (black dots) density is decreased in estrogen receptor β-enhanced green fluorescent protein (EGFP)-containing dendrites in young females, and increased in males and aged females. Scale bar = 500 nm.

    12. Species-specific differences in the medial prefrontal projections to the pons between rat and rabbit

      Maria V. Moya, Jennifer J. Siegel, Eedann D. McCord, Brian E. Kalmbach, Nikolai Dembrow, Daniel Johnston and Raymond A. Chitwood

      Accepted manuscript online: 22 FEB 2014 09:29PM EST | DOI: 10.1002/cne.23566

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      Anterograde tracer injections in prefrontal cortex of rats and rabbits revealed different pontine projection patterns, including a lack of contralateral input in rabbits. The results have implications when manipulating these brain regions to test their putative roles in trace eyeblink conditioning between species.

    13. Increased Neuronal Expression of Neurokinin-1 Receptor and Stimulus-Evoked Internalization of the Receptor in the Rostral Ventromedial Medulla of the Rat after Peripheral Inflammatory Injury

      Marta V. Hamity, Roxanne Y. Walder and Donna L. Hammond

      Accepted manuscript online: 22 FEB 2014 09:27PM EST | DOI: 10.1002/cne.23564

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      Following peripheral inflammatory injury, substance P assumes a pronociceptive role in the brainstem. Mechanisms that underlie this transition include an increase in neurokinin-1 receptor expressing neurons, determined using stereology, and facilitated release of substance P in response to heat stimulation, as evidenced by an increase in neurons exhibiting receptor internalization.

    14. Spatiotemporal distribution of SUMOylation components during mouse brain development

      Yuta Hasegawa, Daisuke Yoshida, Yuki Nakamura and Shin-ichi Sakakibara

      Accepted manuscript online: 20 FEB 2014 04:13AM EST | DOI: 10.1002/cne.23563

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      SUMO is a family of ubiquitin-like small proteins that modify the functions of target proteins post-translationally. Using immunohistochemical and immunoblot analysis, the authors show the developmentally regulated distribution of SUMOylation components in the brain, and the persistent accumulation of SUMO2/3 throughout life in neural progenitor cells residing in the adult subventricular zone and hippocampal dentate gyrus.

    15. Restoration of quinine-stimulated Fos-immunoreactive neurons in the central nucleus of the amygdala and gustatory cortex following reinnervation or cross-reinnervation of the lingual taste nerves in rats

      Camille Tessitore King, Mircea Garcea and Alan C. Spector

      Accepted manuscript online: 29 JAN 2014 12:56PM EST | DOI: 10.1002/cne.23546

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      Lingual gustatory nerves were transected and made to regenerate normally or cross-rewired into non-native regions of the tongue. Analysis of the Fos response to a bitter tastant in two key forebrain regions has revealed the remarkable ability of the central gustatory system to adapt to reorganized peripheral input and has helped elucidate the neural circuitry involved in bitter taste processing.

    16. A unique ion channel clustering domain on the axon initial segment of mammalian neurons

      Anna N. King, Colleen F. Manning and James S. Trimmer

      Accepted manuscript online: 29 JAN 2014 12:41PM EST | DOI: 10.1002/cne.23551

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      Using multiple label immunofluorescence combined with structured illumination microscopy, the authors reveal a unique ion channel clustering domain on the axon initial segment. This specialized compartment within the axon initial segment contains components of diverse signaling pathways that contribute to the function and plasticity of this important neuronal domain.

    17. DSCAM localization and function at the mouse cone synapse

      Gabriel Belem de Andrade, Samuel S. Long, Harrison Fleming, Wei Li and Peter G. Fuerst

      Accepted manuscript online: 29 JAN 2014 12:40PM EST | DOI: 10.1002/cne.23552

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      The authors assay organization of the mouse outer plexiform layer of the retina in the absence of the cell adhesion molecule DSCAM. The outer plexiform layer contains complex synapses between cone photoreceptors and bipolar and horizontal cells. Cone synapses form in the absence of Dscam, but defects in self-avoidance were observed in two populations of OFF bipolar cells. Localization of the DSCAM protein was assayed and the protein was observed on the post-synaptic face of the cone synapse in mouse, ground squirrel and macaque.

    18. Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus

      Christina Herold, Verner P. Bingman, Felix Ströckens, Sara Letzner, Magdalena Sauvage, Nicola Palomero-Gallagher, Karl Zilles and Onur Güntürkün

      Accepted manuscript online: 29 JAN 2014 12:37PM EST | DOI: 10.1002/cne.23549

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      By using receptor autoradiography for eleven different neurotransmitter receptors and zinc labeling the authors mapped the hippocampal formation in the pigeon's brain (A). Comparisons between receptor densities in the pigeon and in the mammalian hippocampal formation (B) showed similarities (indicated by the same colors) between subdivisions in both species.

    19. Concordant localization of functional urotensin II and urotensin II-Related peptide binding sites in the rat brain: Atypical occurrence close to the fourth ventricle

      Christine Bucharles, Patrice Bizet, Sébastien Arthaud, Arnaud Arabo, Jérôme Leprince, Benjamin Lefranc, Dorthe Cartier, Youssef Anouar and Isabelle Lihrmann

      Accepted manuscript online: 29 JAN 2014 12:37PM EST | DOI: 10.1002/cne.23553

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      The present study revealed that [125I]-UII and –URP-binding site distributions overlapped at the regional level in the adult rat brain. Atypical binding sites were unraveled in cell rafts joining the fourth ventricle and its lateral recess. c-Fos positive cells were detected in the same area after UII or URP icv injection, suggesting that these binding sites were functional. These data support a role for UII/URP at the interface between brain tissue and cerebrospinal fluid.

    20. Systematic analysis of neuronal wiring of the rodent deep cerebellar nuclei reveals differences reflecting adaptations at the neuronal circuit and internuclear level

      Salah Hamodeh, Joan Baizer, Izumi Sugihara and Fahad Sultan

      Accepted manuscript online: 29 JAN 2014 12:35PM EST | DOI: 10.1002/cne.23545

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      The authors quantified and charted the major components of the neuropil in the four deep cerebellar nuclei (DCN) of the rat's brain using a quantitative 3D immunohistochemical method they segmented and traced the neuropil stained with antibodies. The authors are able to confirm differences in dendritic and axonal fiber length density, average fiber diameters and volume fraction within the four different nuclei that comprise the DCN. These differences may relate to the phylogenetical status of these nuclei.

    21. Topography and architecture of visual and somatosensory areas of the agouti

      I.A. Dias, C.P. Bahia, J.G. Franca, J.C. Houzel, R. Lent, A.O. Mayer, L.F. Santiago, L.C.L. Silveira, C.W. Picanço-Diniz and A. Pereira

      Accepted manuscript online: 29 JAN 2014 12:32PM EST | DOI: 10.1002/cne.23550

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      The authors demonstrate the presence of multiple sensory areas in the agouti's brain, some of them with isomorphic modules, as demonstrated with a metabolic marker, cytochrome oxidase (CO). The peculiarities of the agouti's brain and body relationship establish it as a useful model for comparative studies of brain evolution

    22. Correlating habenular subnuclei in rat and mouse using topographical, morphological and cytochemical criteria

      Franziska Wagner, Thomas Stroh and Rüdiger W. Veh

      Accepted manuscript online: 29 JAN 2014 12:31PM EST | DOI: 10.1002/cne.23554

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      The mammalian habenula has received much attention recently. Unfortunately, for the mouse the medial and lateral habenular complexes have not been characterized in detail yet. This report, therefore, aimed to use topographical, structural, and cytochemical criteria derived from the rat to define corresponding subnuclear areas within the mouse habenula.


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