Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at chronic stage
Svitlana Garbuzova-Davis, Edward Haller, Stephanie N. Williams, Eithan D. Haim, Naoki Tajiri, Diana G. Hernandez-Ontiveros, Aric Frisina-Deyo, Sean M. Boffeli, Paul R. Sanberg and Cesario V. Borlongan
Accepted manuscript online: 8 MAR 2014 06:02AM EST | DOI: 10.1002/cne.23582
Results from our study show not only significant BBB alterations in the ipsilateral hemisphere, but also demonstrate, for the first time, changes in the contralateral hemisphere 30 days after an ischemic insult using a transient MCAO rat model. These widespread microvascular alterations in ipsi- and contralateral hemispheres shown to be closely associated with BBB breakdown in chronic ischemia represent novel findings.